N-<2-(4-monomethoxytrityl)aminoethyl>aminomethyldiphenyl phosphonate | 203643-15-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N-<2-(4-monomethoxytrityl)aminoethyl>aminomethyldiphenyl phosphonate
• CAS: 203643-15-6
• 化学式: C₃₅H₃₅N₂O₄P
• 分子量: 578.648
• InChiKey: VZMJKJVCNSKUHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.47
• 重原子数：
  42.0
• 可旋转键数：
  14.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  68.82
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  N-<2-(4-monomethoxytrityl)aminoethyl>aminomethyldiphenyl phosphonate 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole 、 三苯基膦 作用下， 以 四氯化碳 为溶剂， 生成
  参考文献：
  名称：

  Synthesis And Binding Study Of Phosphonate Analogues Of Pnas And Their Hybrids With Pnas

  摘要：

  The preparation of monomers for time synthesis of phosphonate analogues of peptide nucleic acids containing the four natural nucleobases: thymine, cytosine, adenine and guanine, has been ccomplished. The monomers obtained were used for the automated online solid phase synthesis of pure phosphono-PNA oligomers as well as chimeras consisting of phosphono-PNA and]PNA resudies. The hybridization properties of these oligonucleotide mimics to complementary DNA and RNA fragments were studied.

  DOI：

  10.1080/07328319808004700
• 作为产物：
  描述：

  聚合甲醛 、 亚磷酸二苯酯 、 N1-((4-methoxyphenyl)diphenylmethyl)ethane-1,2-diamine 生成 N-<2-(4-monomethoxytrityl)aminoethyl>aminomethyldiphenyl phosphonate
  参考文献：
  名称：

  Synthesis And Binding Study Of Phosphonate Analogues Of Pnas And Their Hybrids With Pnas

  摘要：

  The preparation of monomers for time synthesis of phosphonate analogues of peptide nucleic acids containing the four natural nucleobases: thymine, cytosine, adenine and guanine, has been ccomplished. The monomers obtained were used for the automated online solid phase synthesis of pure phosphono-PNA oligomers as well as chimeras consisting of phosphono-PNA and]PNA resudies. The hybridization properties of these oligonucleotide mimics to complementary DNA and RNA fragments were studied.

  DOI：

  10.1080/07328319808004700

文献信息

• Efimov; Buryakova; Choob, Russian Journal of Bioorganic Chemistry, 1998, vol. 24, # 9, p. 618 - 630
  作者：Efimov、Buryakova、Choob、Chakhmakhcheva

  DOI：——

  日期：——