4,5-二氢-3-(4-吡啶基)-2H-苯并[G]吲唑甲烷磺酸盐 | 80997-85-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 4,5-二氢-3-(4-吡啶基)-2H-苯并[G]吲唑甲烷磺酸盐
• 中文别名: 4,5-二氢-3-(4-吡啶)-2H-苯并(g)-吲唑甲磺酸盐
• 英文名称: methanesulfonate;3-pyridin-1-ium-4-yl-4,5-dihydro-1H-benzo[g]indazole
• CAS: 80997-85-9
• 化学式: C17H17N3O3S
• 分子量: 343.4
• InChiKey: SGKSWXAABLWFHI-UHFFFAOYSA-N

物化性质

• 熔点：
  275 °C (subl.)(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  3.22
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.176
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• TPL-2/COT kinase and methods of use
  申请人：——

  公开号：US20030219427A1

  公开（公告）日：2003-11-27

  It is shown that TPL-2 is responsible for phosphorylation of p105 and its resultant proteolysis, which leads to p50 Rel translocation to the nucleus. Accordingly, the invention provides TPL-2 as a specific regulator of the activation of NF&kgr;B, and thus as a modulator of inflammatory responses in which p1O5 is involved, and as a target for the development of compounds capable of influencing NF&kgr;B activation.

  研究表明，TPL-2 负责 p105 的磷酸化及其蛋白水解，从而导致 p50 Rel 转位至细胞核。因此，本发明提供的 TPL-2 是 NF&kgr;B 活化的特异性调节剂，因而是 p1O5 参与的炎症反应的调节剂，也是开发能够影响 NF&kgr;B 活化的化合物的靶标。
• TPL-2/COT KINASE AND METHODS OF USE
  申请人：BASF Aktiengesellschaft

  公开号：EP1105501A2

  公开（公告）日：2001-06-13
• JP2002531058A
  申请人：——

  公开号：JP2002531058A

  公开（公告）日：2002-09-24
• JP4719831B2
  申请人：——

  公开号：JP4719831B2

  公开（公告）日：2011-07-06
• [EN] TPL-2/COT KINASE AND METHODS OF USE<br/>[FR] KINASE TPL-2/COT ET SES PROCEDES D'UTILISATION
  申请人：BASF AG

  公开号：WO2000011191A2

  公开（公告）日：2000-03-02

  It is shown that TPL-2 is responsible for phosphorylation of p105 and its resultant proteolysis, which leads to p50 Rel translocation to the nucleus. Accordingly, the invention provides TPL-2 as a specific regulator of the activation of NFλB, and thus as a modulator of inflammatory responses in which p105 is involved, and as a target for the development of compounds capable of influencing NFλB activation.

表征谱图