1-benzyl-3-ethyl-3-methyl-4-piperidinone | 373603-99-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-benzyl-3-ethyl-3-methyl-4-piperidinone
• 英文别名: 1-benzyl-3-ethyl-3-methylpiperidin-4-one
• CAS: 373603-99-7
• 化学式: C₁₅H₂₁NO
• 分子量: 231.338
• InChiKey: RAWKFELASWZAQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-benzyl-3-ethyl-3-methyl-4-piperidinone 在 氢氧化钾 、 盐酸甲胺 、 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 生成 1-benzyl-4-methylamino-3-ethyl-3-methylpiperidine
  参考文献：
  名称：

  Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments

  摘要：

  这项发明涉及新一代三靶向手性广谱抗菌7-取代哌啶喹啉羧酸衍生物，以及它们的光学异构体、二对映异构体或对映异构体，以及它们的药用盐、水合物、前药、多型和伪多型，以及它们的制备、组合物和用途。

  公开号：

  US06878713B2
• 作为产物：
  描述：

  1-苄基-3-乙基-4-哌啶酮 、 potassium tert-butylate 、 碘甲烷 、 水 在 乙酸乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 17.42h， 以furnished 1-benzyl-3-ethyl-3-methylpiperid-4-one as oil, which的产率得到1-benzyl-3-ethyl-3-methyl-4-piperidinone
  参考文献：
  名称：

  Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment

  摘要：

  本发明涉及光学纯的8-(取代哌啶基)-苯[i,j]喹啉，它们的异构体、衍生物、盐、伪多晶体、多晶体、前药和水合物，以及它们的制备方法和包含8-(取代哌啶基)-苯[i,j]喹啉、它们的异构体、衍生物、盐、伪多晶体、多晶体和水合物的药物组合物。这些化合物和组合物在治疗局部和全身感染方面具有强效活性，特别是对敏感和耐药革兰氏阳性菌感染、革兰氏阴性菌感染、分枝杆菌感染和医院感染病原体，特别是属于葡萄球菌、链球菌和肠球菌群的感染具有活性。通过将本发明的化合物用于人类和动物治疗上述感染引起的疾病和疾病的方法也被描述。

  公开号：

  US20020165227A1

文献信息

• Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation,compositions and use as medicaments
  申请人：WOCKHARDT LIMITED

  公开号：US20030216568A1

  公开（公告）日：2003-11-20

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向手性广谱抗菌7-取代哌啶酮羧酸衍生物，以及它们的光学异构体、对映异构体或对映体，以及其药学上可接受的盐、水合物、前药、多晶形和假多晶形，以及它们的制备、组成和用途。
• Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-Quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
  申请人：WOCKHARDT LIMITED

  公开号：US20030096812A1

  公开（公告）日：2003-05-22

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向手性广谱抗微生物7-取代哌啶酮羧酸衍生物，其光学异构体，对映异构体或对映体，以及其药学上可接受的盐，水合物，前药，多晶形和假多晶形，以及其制备，组成和使用。
• Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
  申请人：Wockhardt Limited

  公开号：US06608078B2

  公开（公告）日：2003-08-19

  The present invention relates to optically pure 8-(substituted piperidino)-benzo[i,j]quinolizines, their isomers, derivatives, salts, pseudopolymorphs, polymorphs prodrugs and hydrates thereof, to processes for their preparation, and to pharmaceutical compositions comprising 8-(substituted piperidino)-benzo[i,j]quinolizines their isomers, derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof. These compounds and compositions possess potent activity in treating local and systemic infections, particularly infections caused by sensitive and resistant Gram-positive organism infections, Gram-negative organism infections, mycobacterial infections and nosocomial pathogens, and particularly those belonging to the staphylococcus, streptococcus and enterococcus groups. Methods for treating the diseases and disorders arising from the foregoing infections in humans and animals are described by administering the compounds of the invention to said humans and animals.

  本发明涉及光学纯的8-（取代哌啶基）-苯并[i,j]喹啉，它们的异构体，衍生物，盐，伪多型，多型前药和水合物，以及它们的制备过程，以及包括8-（取代哌啶基）-苯并[i,j]喹啉，它们的异构体，衍生物，盐，伪多型，多型和水合物的制药组合物。这些化合物和组合物具有在治疗局部和全身感染方面的强效活性，特别是对于由敏感和耐药革兰氏阳性菌感染，革兰氏阴性菌感染，分枝杆菌感染和医院感染病原体引起的感染，特别是属于葡萄球菌，链球菌和肠球菌群的感染。通过将本发明的化合物用于人类和动物，可以描述用于治疗由上述感染引起的疾病和疾病的方法。
• New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
  申请人：De Souza Noel John

  公开号：US20080214608A1

  公开（公告）日：2008-09-04

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向手性广谱抗微生物7-取代哌啶酮羧酸衍生物，以及它们的光学异构体、对映异构体或对映体，以及药学上可接受的盐、水合物、前药、多晶形和伪多晶形，以及它们的制备、组成和使用。
• CHIRAL BROAD-SPECTRUM ANTIBACTERIAL 7-SUBSTITUTED PIPERIDINO-QUINOLONE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS
  申请人：Wockhardt Limited

  公开号：EP1392677A2

  公开（公告）日：2004-03-03