1-((2,6-dimethoxypyridin-3-yl)methyl)-4-(2,4-dimethylphenyl)piperazine | 1206846-48-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-((2,6-dimethoxypyridin-3-yl)methyl)-4-(2,4-dimethylphenyl)piperazine
• 英文别名: 1-[(2,6-Dimethoxypyridin-3-yl)methyl]-4-(2,4-dimethylphenyl)piperazine
• CAS: 1206846-48-1
• 化学式: C₂₀H₂₇N₃O₂
• 分子量: 341.453
• InChiKey: OKWJCUMSTLNJLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  37.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 5HT7 receptor ligands and compositions comprising the same
  申请人：Laboratorios Del. Dr. Esteve, S.A.

  公开号：EP2149373A1

  公开（公告）日：2010-02-03

  The present invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, especially as agonists, identified by using a pharmacophore and a descriptor's profile filter as well as to pharmaceutical compositions comprising them. These compounds are useful in therapy in particular for the treatment and or prophylaxis of a disease in which 5-HT7 is involved, such as CNS disorders.

  本发明涉及具有药理活性的化合物，特别是作为5-HT7受体激动剂，通过使用药效团和描述符的配置文件筛选识别，以及包含它们的药物组合物。这些化合物在治疗中特别有用，特别是用于治疗和/或预防涉及5-HT7的疾病，如中枢神经系统紊乱。
• 5HT7 RECEPTOR LIGANDS AND COMPOSITIONS COMPRISING THE SAME
  申请人：Laboratorios del. Dr. Esteve, S.A.

  公开号：EP2344162A2

  公开（公告）日：2011-07-20
• [EN] 5HT7 RECEPTOR LIGANDS AND COMPOSITIONS COMPRISING THE SAME<br/>[FR] LIGANDS DU RÉCEPTEUR 5-HT7 ET COMPOSITIONS LES CONTENANT
  申请人：ESTEVE LABOR DR

  公开号：WO2010012817A2

  公开（公告）日：2010-02-04

  The present invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, especially as agonists, identified by using a pharmacophore and a descriptor's profile filter as well as to pharmaceutical compositions comprising them. These compounds are useful in therapy in particular for the treatment and or prophylaxis of a disease in which 5-HT7 is involved, such as CNS disorders.