3-{4-[2-(3-cyclopentyl-1-heptylureido)ethoxy]phenyl}-2-ethoxypropionic acid | 586974-55-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-{4-[2-(3-cyclopentyl-1-heptylureido)ethoxy]phenyl}-2-ethoxypropionic acid
• 英文别名: 3-[4-[2-[Cyclopentylcarbamoyl(heptyl)amino]ethoxy]phenyl]-2-ethoxypropanoic acid
• CAS: 586974-55-2
• 化学式: C₂₆H₄₂N₂O₅
• 分子量: 462.63
• InChiKey: AQYACEBLSOLGGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  33
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  88.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Novel propionic acid derivatives
  申请人：——

  公开号：US20040072690A1

  公开（公告）日：2004-04-15

  A compound represented by the following formula (1) or a salt thereof: 1 wherein R 1 represents a C 1-12 alkyl group, phenyl group, 1-naphthyl group and the like, R 2 represents a C 2-12 alkyl group, (R 3 ) b represents 0 to 4 substituents such as a halogen atom, R 4 represents a lower alkyl group, R 5 represents hydrogen atom or a lower alkyl group, n represents an integer from 2 to 4, and X represents —NH— or —O—, which has superior hypoglycemic action, hypolipidemic action and total cholesterol reducing action, and is useful as an active ingredient of a medicament for prophylactic and/or therapeutic treatment of diseases including diabetes mellitus, hyperlipidemia and the like.

  以下化合物的分子式（1）或其盐：其中R1代表C1-12烷基基团、苯基、1-萘基等，R2代表C2-12烷基基团，（R3）b代表0至4个卤原子等取代基，R4代表较低的烷基基团，R5代表氢原子或较低的烷基基团，n代表2至4的整数，X代表—NH—或—O—，具有优越的降糖作用、降脂作用和总胆固醇降低作用，可用作预防和/或治疗糖尿病、高脂血症等疾病的药物的活性成分。
• NOVEL PROPIONIC ACID DERIVATIVE
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP1484316A1

  公开（公告）日：2004-12-08

  A compound represented by the following formula (1) or a salt thereof: wherein R1 represents a C1-12 alkyl group, phenyl group, 1-naphthyl group and the like, R2 represents a C2-12 alkyl group, (R3)b represents 0 to 4 substituents such as a halogen atom, R4 represents a lower alkyl group, R5 represents hydrogen atom or a lower alkyl group, n represents an integer from 2 to 4, and X represents -NH- or -O-, which has superior hypoglycemic action, hypolipidemic action and total cholesterol reducing action, and is useful as an active ingredient of a medicament for prophylactic and/or therapeutic treatment of diseases including diabetes mellitus, hyperlipidemia and the like.

  下式（1）代表的化合物或其盐： 其中 R1 代表 C1-12 烷基、苯基、1-萘基等，R2 代表 C2-12 烷基，(R3)b 代表 0 至 4 个取代基，如卤素原子，R4 代表低级烷基，R5 代表氢原子或低级烷基，n 代表 2 至 4 的整数、X代表-NH-或-O-，它具有优异的降血糖作用、降血脂作用和降低总胆固醇作用，可用作预防和/或治疗糖尿病、高脂血症等疾病的药物活性成分。
• US7015345B2
  申请人：——

  公开号：US7015345B2

  公开（公告）日：2006-03-21