2,3-dimethoxynaphthalen-1-ol | 1609179-51-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2,3-dimethoxynaphthalen-1-ol
• 英文别名: Dimethoxynaphthol
• CAS: 1609179-51-2
• 化学式: C₁₂H₁₂O₃
• 分子量: 204.225
• InChiKey: UVVULNQVONULGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-溴-2,3-二甲氧基萘 在 2-二叔丁基膦-2′,4′,6′-三异丙基-3,6-二甲氧基-1,1′-联苯 、 C₄₄H₆₂NO₅PPdS 、 水 、 potassium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 18.0h， 以99%的产率得到2,3-dimethoxynaphthalen-1-ol
  参考文献：
  名称：

  Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst

  摘要：

  A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (1,5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.

  DOI：

  10.1021/jo500662s

文献信息

• NOVEL INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS
  申请人：TRANSITIONS OPTICAL, INC.

  公开号：EP1214311A1

  公开（公告）日：2002-06-19
• [EN] NOVEL INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS<br/>[FR] NOUVEAUX NAPHTHOPYRANES PHOTOCHROMIQUES INDENOFUSIONNES
  申请人：TRANSITIONS OPTICAL INC

  公开号：WO2001019813A1

  公开（公告）日：2001-03-22

  Described are novel photochromic indeno-fused naphthopyran compounds, examples of which include naphthopyran compounds having a substituted or unsubstituted indeno group, the 2,1 positions of which are fused to the naphtho portion of the naphthopyran. Also present on the naphthopyran are moderate to strong electron donor substituents at the number 6- and 7-positions and optionally at the 8-position of the pyran ring or a cyclic group fused to the h side of the naphtho portion and weak to moderate electron donor substituents at the 3-position of the pyran ring. Certain substituents may also be present at the number 5, 8, 9, 10, 11, 12, or 13 carbon atoms of the compounds. These compounds have a rating of at least 80 in the Relative ΔOD at Saturation Test and may be represented by graphic formula (I): Also described are polymeric organic host materials that contain or that are coated with such compounds. Optically clear articles such as ophthalmic lenses or other plastic transparencies that incorporate the novel naphthopyran compounds or combinations thereof with complementary photochromic compounds, e.g., certain other naphthopyrans, benzopyrans, and spiro(indoline) type compounds, are also described.
• [EN] ENHANCED COLOUR DEPOSITION FOR HAIR WITH SEQUESTERING AGENTS<br/>[FR] DEPOT DE COLORATION POUR CHEVEUX AMELIORE PAR DES AGENTS SEQUESTRANTS
  申请人：UNILEVER PLC

  公开号：WO2003053386A1

  公开（公告）日：2003-07-03

  Hair colouring compositions which comprise: A) non-nitrogenous chelating agents from the groupconsisting of polyphosphate; phosphonates;hydroxycarboxylates; polyacrylates; zeolite; and mixtures thereof; B) an oxidative dye primary intermediate; and C) an oxidative dye coupler; D) and waterare described.The present invention also relates to a method for colouring hair which comprises contracting said hair with a haircolouring composition as described above.
• [EN] ONE STEP HAIR COLORING COMPOSITIONS COMPRISING WATER SOLUBLE CARBONATE RELEASING SALTS<br/>[FR] COMPOSITIONS DE COLORATION CAPILLAIRE EN UNE ETAPE RENFERMANT DES SELS A LIBERATION DE CARBONATE DE TYPE HYDROSOLUBLE
  申请人：UNILEVER PLC

  公开号：WO2004014328A1

  公开（公告）日：2004-02-19

  A hair coloring composition comprising the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an amino phenol, a naphthol, a polyhydric phenol, a catechol and mixtures thereof; wherein the composition comprising one or more oxidative hair coloring agents further comprises al least one water soluble carbonate releasing salts; and optionally a water soluble ammonium salt,is described.
• Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst
  作者：Chi Wai Cheung、Stephen L. Buchwald

  DOI：10.1021/jo500662s

  日期：2014.6.6

  A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (1,5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.