N-[3,5-bis(1-piperidinomethyl)-4-hydroxyphenyl]-1-naphthalenesulfonamide | 343935-63-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[3,5-bis(1-piperidinomethyl)-4-hydroxyphenyl]-1-naphthalenesulfonamide
• 英文别名: N-[4-hydroxy-3,5-bis(piperidin-1-ylmethyl)phenyl]naphthalene-1-sulfonamide
• CAS: 343935-63-7
• 化学式: C₂₈H₃₅N₃O₃S
• 分子量: 493.67
• InChiKey: DBCNKGXXJRGZRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  81.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• N-SUBSTITUTED BENZYL OR PHENYL AROMATIC SULFAMIDES COMPOUNDS AND THE USE THEREOF
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：EP1245561A1

  公开（公告）日：2002-10-02

  N-(3,5-bis-disubstituted aminomethyl-4-hydroxy)benzyl aromatic sulfonamides and N-(3,5-bis-disubstituted aminomethyl-4-hydroxy)phenyl aromatic sulfonamides compounds in accordance with the animal test, are active in the prevention and the treatment of cardiac arrhythmia. These compounds are prepared as corresponding diamines by the condensation of optionally substituted aromatic sulfochlorides with p-hydroxybenzylamine, p-aminophenol, or the like, which followed by the Mannich reaction of the resulted corresponding aromatic sulfamides with formaldehyde and secondary amines; or directly obtained by the reaction of the aromatic sulfamides with 4-amino-2,6-bis-disubstituted aminomethylphenol. Subsequently, the diamines are reacted with various acids to provide their salts.

  根据动物试验，N-(3,5-二取代氨甲基-4-羟基)苄基芳香族磺酰胺和 N-(3,5-二取代氨甲基-4-羟基)苯基芳香族磺酰胺化合物在预防和治疗心律失常方面具有活性。这些化合物是通过任选取代的芳香族磺酰氯与对羟基苄胺、对氨基苯酚或类似物缩合，然后将生成的相应芳香族磺酰胺与甲醛和仲胺进行曼尼希反应制备成相应的二胺；或者直接通过芳香族磺酰胺与 4-氨基-2,6-二取代氨甲基苯酚反应制备成二胺。随后，二胺与各种酸反应生成它们的盐。
• US6605635B1
  申请人：——

  公开号：US6605635B1

  公开（公告）日：2003-08-12