(4-chlorophenyl)(4-(2,6-difluorophenyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol | 1202160-11-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (4-chlorophenyl)(4-(2,6-difluorophenyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol
• CAS: 1202160-11-9
• 化学式: C₂₆H₂₂ClF₂N₃O
• 分子量: 465.93
• InChiKey: ZPFBGQMMRRWODL-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  (4-chlorophenyl)(4-(2,6-difluorophenyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol 在 manganese(IV) oxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以60%的产率得到(4-chlorophenyl)(4-(2,6-difluorophenyl)isoquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol
  参考文献：
  名称：

  Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents

  摘要：

  We developed a synthetic route to prepare isoquinoline analogs of the cancer drug clinical candidate tipifarnib. We show that these compounds kill Trypanosoma cruzi amastigotes grown in mammalian host cells at concentrations in the low nanomolar range. These isoquinolines represent new leads for the development of drugs to treat Chagas disease. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.029
• 作为产物：
  描述：

  (4-chlorophenyl)(4-(2,6-difluorophenyl)-2-trityl-1,2,3,4-tetrahydroisoquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol 在 三氟乙酸 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 以80%的产率得到(4-chlorophenyl)(4-(2,6-difluorophenyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol
  参考文献：
  名称：

  Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents

  摘要：

  We developed a synthetic route to prepare isoquinoline analogs of the cancer drug clinical candidate tipifarnib. We show that these compounds kill Trypanosoma cruzi amastigotes grown in mammalian host cells at concentrations in the low nanomolar range. These isoquinolines represent new leads for the development of drugs to treat Chagas disease. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.029