8-chloro-2-hydroxynaphthalene-1,4-dione | 103037-71-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 8-chloro-2-hydroxynaphthalene-1,4-dione
• 英文别名: 5-Chloro-3-hydroxy-<1,4>naphthoquinone
• CAS: 103037-71-4
• 化学式: C₁₀H₅ClO₃
• 分子量: 208.601
• InChiKey: OVQFIGMIKAOWPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.16
• 重原子数：
  14.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.37
• 氢给体数：
  1.0
• 氢受体数：
  3.0

文献信息

• [EN] NAPTHOQUINONES, PRO-DRUGS, AND METHODS OF USE THEREOF<br/>[FR] NAPHTOQUINONES, PROMÉDICAMENTS, ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV TEXAS

  公开号：WO2017106624A1

  公开（公告）日：2017-06-22

  Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.

  提供在本说明书中的萘醌化合物，例如具有式(I)中的氢键供体基团的那些：其中：R1、R2、R3、R4、R5和n如本文所述定义。此外，还提供了本化合物的药物组合物以及使用这些化合物进行治疗的方法，包括它们在癌症治疗中的应用。
• Naphthoquinones, pro-drugs, and methods of use thereof
  申请人：The Board of Regents of the University of Texas System

  公开号：US10829427B2

  公开（公告）日：2020-11-10

  Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.

  本文提供的萘醌化合物，例如具有式（I）氢键捐赠基团的萘醌化合物： 其中：R1、R2、R3、R4、R5 和 n 如本文所定义。本文还提供了本化合物的药物组合物和使用本化合物的治疗方法，包括用于治疗癌症的方法。
• NAPHTHOQUINONES, PRO-DRUGS, AND METHODS OF USE THEREOF
  申请人：The Board of Regents of the University of Texas System

  公开号：US20190071380A1

  公开（公告）日：2019-03-07

  Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R 1 , R 2 , R 3 , R 4 , R 5 , and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.