N-{(1RS,2RS)-2-(4-chlorophenyl)-1-methyl-6-(2-naphthyl)hexyl}-N-(2-naphthylmethyl)carbamoylmethyl-succinic acid | 178103-96-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-{(1RS,2RS)-2-(4-chlorophenyl)-1-methyl-6-(2-naphthyl)hexyl}-N-(2-naphthylmethyl)carbamoylmethyl-succinic acid
• 英文别名: 2-[2-[[3-(4-Chlorophenyl)-7-naphthalen-2-ylheptan-2-yl]-(naphthalen-2-ylmethyl)amino]-2-oxoethyl]butanedioic acid
• CAS: 178103-96-3
• 化学式: C₄₀H₄₀ClNO₅
• 分子量: 650.214
• InChiKey: PWPNJZDBKNZWMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  47
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  94.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• MEDICINAL COMPOSITION
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0856315A1

  公开（公告）日：1998-08-05

  The present invention relates to an antitumor or anti-AIDS composition containing a protein-farnesyltransferase inhibitor and an agent which decreases farnesyl pyrophosphate in vivo as active ingredients.

  本发明涉及一种抗肿瘤或抗艾滋病组合物，其活性成分含有一种蛋白-法尼基转移酶抑制剂和一种能减少体内焦磷酸法尼基的制剂。
• METHODS OF TREATMENT OF OCULAR NEOVASCULARIZATION
  申请人：——

  公开号：US20020006967A1

  公开（公告）日：2002-01-17

  The present invention includes methods for treatment and prophylaxis of eye disorders and injuries, particularly treatment and prophylaxis of ocular neovascularization and disorders, especially a vasculopathy that affects retinal or chorodial vessels. The methods of the invention in general comprise administration of a therapeutically effective amount of a compound that inhibits farnesyl-protein transferase to a subject suffering from or susceptible to ocular neovascularization or associated disorder.

  本发明包括治疗和预防眼部疾病和损伤的方法，特别是治疗和预防眼部新生血管和疾病，尤其是影响视网膜或脉络膜血管的血管病变。本发明的方法一般包括向患有或易患眼部新生血管或相关疾病的受试者施用治疗有效量的抑制法尼基蛋白转移酶的化合物。
• SUBSTITUTED AMIDE DERIVATIVE
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0776884B1

  公开（公告）日：2000-01-05
• PROTEIN-FARNESYLTRANSFERASE INHIBITORS IN COMBINATION WITH HMGCOA-REDUCTASE-INHIBITORS FOR THE TREATMENT OF AIDS
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0856315B1

  公开（公告）日：2005-08-24
• US5643958A
  申请人：——

  公开号：US5643958A

  公开（公告）日：1997-07-01