[1-(1-isopropyl-piperidin-2-yl)-1-methyl-ethyl]-(8-naphthalen-2-yl-7-pyridin-4-yl-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-amine | 534602-69-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [1-(1-isopropyl-piperidin-2-yl)-1-methyl-ethyl]-(8-naphthalen-2-yl-7-pyridin-4-yl-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-amine
• 英文别名: 8-naphthalen-2-yl-N-[2-(1-propan-2-ylpiperidin-2-yl)propan-2-yl]-7-pyridin-4-yl-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
• CAS: 534602-69-2
• 化学式: C₃₁H₃₅N₇
• 分子量: 505.666
• InChiKey: KVOKRVAXAVLQPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  71.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Substituted indolizine-like compounds and methods of use
  申请人：——

  公开号：US20030195221A1

  公开（公告）日：2003-10-16

  Selected novel substituted indolizine-like compounds are effective for treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for treatment of diseases and other maladies or conditions involving inflammation, cancer, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的类似吲哚啉的化合物对治疗疾病，如TNF-α、IL-1β、IL-6和/或IL-8介导的疾病，以及其他疾病，如癌症、疼痛和糖尿病具有有效性。本发明涵盖了新型化合物、类似物、前药和其药用可接受盐、制药组合物以及治疗涉及炎症、癌症、疼痛、糖尿病等疾病和其他疾患或情况的方法。该发明还涉及制备此类化合物的方法，以及在此类过程中有用的中间体。
• [EN] INHIBITORS OF TUBULIN POLYMERIZATION<br/>[FR] INHIBITEURS DE LA POLYMERISATION DE TUBULINE
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2003070241A1

  公开（公告）日：2003-08-28

  The invention relates to the inhibition of tubulin polymerization. The invention provides compounds and methods for inhibiting tubulin polymerization. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及抑制微管聚合。本发明提供了抑制微管聚合的化合物和方法。本发明还提供了治疗细胞增殖性疾病和状况的组合物和方法。
• SUBSTITUTED INDOLIZINE-LIKE COMPOUNDS AND METHODS OF USE
  申请人：Amgen Inc.

  公开号：EP1448564A2

  公开（公告）日：2004-08-25
• INHIBITORS OF TUBULIN POLYMERIZATION
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP1480645A1

  公开（公告）日：2004-12-01
• EP1480645A4
  申请人：——

  公开号：EP1480645A4

  公开（公告）日：2006-03-29