2-propyl 1,3-benzylidine glycerol | 1086452-35-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 2-propyl 1,3-benzylidine glycerol
• 英文别名: 2-Phenyl-5-propoxy-1,3-dioxane
• CAS: 1086452-35-8
• 化学式: C₁₃H₁₈O₃
• 分子量: 222.284
• InChiKey: CRYASUJUWFDQHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• GLYCEROL DERIVATIVES AND METHODS OF MAKING SAME
  申请人：Kodali Dharma R.

  公开号：US20080293602A1

  公开（公告）日：2008-11-27

  Symmetrical polyols, polyol esters, polyesters, polyurethanes, triazoles, and polyvinylethers derived from glycerol and methods of making the symmetrical polyols, polyesters, polyurethanes, polyhydroxyvinylethers and triazoles are discussed. Also provided is a method of making serinol.

  本文讨论了从甘油衍生出的对称聚醇、聚醚醇、聚酯、聚氨酯、三唑和聚乙烯醚，以及制备这些对称聚醇、聚酯、聚氨酯、聚羟基乙烯醚和三唑的方法。此外，还提供了一种制备丝氨醇的方法。
• Fluoropolymer Emulsions with Branched Semifluorinated Block Copolymer or Phospholipid Surfactant for the Delivery of Hydrophobic Drugs
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20170049699A1

  公开（公告）日：2017-02-23

  The present invention provides therapeutic formulations, including therapeutic nanoemulsions, and related methods for the in vivo delivery of hydrophobic compounds, including an important class of hydrophobic anesthetics. Formulations and methods of the invention include semifluorinated block copolymers, and optionally phospholipid surfactants, capable of forming a stable nanoemulsion without the need of conventional lipid components that support bacterial and/or fungal growth (e.g., soybean oil and similar lipids). In certain embodiments, emulsion-based formulations are provided that are capable of formulating, delivering and releasing amounts of hydrophobic drugs effective for a range of clinical applications, including inducing and maintaining anesthesia in patients. In certain embodiments, emulsion-based formulations are provided that are capable of supporting controlled release, for example, over a range of rates useful for clinical applications including rapid and sustained release.
• Fluoropolymer Emulsions with Perhalogenated Stabilizer for the Delivery of Hydrophobic Drugs
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20170100336A1

  公开（公告）日：2017-04-13

  The present invention provides therapeutic formulations, including therapeutic nanoemulsions, and related methods for the in vivo delivery of hydrophobic compounds, including an important class of hydrophobic anesthetics. Formulations and methods of the invention include semifluorinated block copolymers and perhalogenated fluorous compounds, such as perfluorooctyl bromide or perfluorodecalin, capable of forming a stable nanoemulsion without the need of conventional lipid components that support bacterial and/or fungal growth (e.g., soybean oil and similar lipids). In certain embodiments, emulsion-based formulations are provided that are capable of formulating, delivering and releasing amounts of hydrophobic drugs effective for a range of clinical applications, including inducing and maintaining anesthesia in patients. In certain embodiments, emulsion-based formulations are provided that are capable of supporting controlled release, for example, over a range of rates useful for clinical applications including rapid and sustained release.
• IMMUNOMODULATING POLYNUCLEOTIDE CONJUGATES AND METHODS OF USE
  申请人：Tallac Therapeutics, Inc.

  公开号：US20220096649A1

  公开（公告）日：2022-03-31

  Provided herein is a conjugate for modulating a natural killer cell or myeloid cell, comprising a targeting moiety and an immunomodulating polynucleotide. Also provided herein is a pharmaceutical composition for modulating a natural killer cell or myeloid cell, comprising a conjugate comprising a targeting moiety and an immunomodulating polynucleotide, and a pharmaceutically acceptable excipient. Additionally provided herein are methods of their use for modulating a natural killer cell or myeloid cell and treating a proliferative disease.
• US7989555B2
  申请人：——

  公开号：US7989555B2

  公开（公告）日：2011-08-02