5-Isopropyl-1-naphthalenesulfonic acid | 131-26-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-Isopropyl-1-naphthalenesulfonic acid
• 英文别名: 5-propan-2-ylnaphthalene-1-sulfonic acid
• CAS: 131-26-0
• 化学式: C₁₃H₁₄O₃S
• 分子量: 250.32
• InChiKey: QJLACXXJNPNCQK-UHFFFAOYSA-N

物化性质

• 密度：
  1.274±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US20140128388A1

  公开（公告）日：2014-05-08

  Drug candidates for inhibition of HIV-1 replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3-diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-1 viral replication in vitro.

  针对HIV-1复制的药物候选物可以针对Src家族激酶（SFK），例如与病毒的Nef蛋白相互作用的Hck。通过对Nef:SFK复合物中SFK的激酶活性进行测定，鉴定了具有这种抑制活性的化合物。使用激酶测定鉴定的抑制剂的例子包括各种2,3-二氨基喹啉和呋喃[2,3-d]嘧啶。发明的抑制剂被发现可以在体外阻止HIV-1病毒复制。
• Method of hair treatment
  申请人：Kao Corporation

  公开号：EP0662314A1

  公开（公告）日：1995-07-12

  A method of hair treatment comprising applying a hair treating preparation to hair and treating the hair with steam either simultaneously with or after the application of the hair treating preparation, in which said hair treating preparation contains a nonvolatile compound selected from a monoalkyl ether of a polyalkylene glycol, a hydroxycarboxylic acid, a hydroxysulfonic acid, an aromatic sulfonic acid, and a nonionic amphiphilic compound.

  一种头发处理方法，包括在头发上涂抹一种头发处理制剂，并在涂抹头发处理制剂的同时或之后用蒸汽处理头发，其中所述头发处理制剂含有一种非挥发性化合物，该化合物选自聚亚烷基二醇单烷基醚、羟基羧酸、羟基磺酸、芳香族磺酸和非离子两性化合物。
• HAIR TREATMENT METHOD
  申请人：Kao Corporation

  公开号：EP3395323A1

  公开（公告）日：2018-10-31

  A method for treating hair, comprising the following steps: step (i): a step of applying a first composition comprising carboxylic acid having an inorganic value of 250 to 450 and an organic value of 50 to 250, or a salt of the carboxylic acid, as a component (A), to hair, step (ii): a step of leaving the hair, to which the first composition has been applied, at a temperature of 15°C to 100°C for 15 seconds to 60 minutes, and step (iii): a step of applying a second composition comprising aromatic sulfonic acid or a salt thereof having a molecular weight of 300 or less, as a component (B), to the hair after completion of the step (ii).

  一种处理头发的方法，包括以下步骤： 步骤(i)：将第一种组合物涂抹在头发上，该组合物包含无机值为 250 至 450、有机值为 50 至 250 的羧酸或羧酸盐，作为组分(A)、 步骤(ii)：将涂抹了第一种成分的头发在 15°C 至 100°C 的温度下静置 15 秒至 60 分钟，以及 步骤(iii)：在步骤(ii)完成后，在头发上涂抹第二种组合物，该第二种组合物包含芳香族磺酸或其盐，分子量在 300 或以下，作为组分（B）。
• MULTIAGENT-TYPE HAIR TREATMENT AGENT
  申请人：Kao Corporation

  公开号：EP3626224A1

  公开（公告）日：2020-03-25

  A multi -agent type hair treatment agent comprising a first composition containing component (A) and component (B) ; and a second composition containing component (C), wherein the weight ratio (H)/(C) of component (H) to component (C) in the second composition is less than 1. A hair treatment method comprising the steps of applying and rinsing the first composition to hair (i) and then applying the second composition to hair (ii). Component (A) : a carboxylic acid having an inorganic value of 230 or more and 450 or less and an organic value of 50 or more and 250 or less, or a salt of the carboxylic acid Component (B): anionic surfactant Component (C) : an aromatic sulfonic acid having amolecular weight of 300 or less or a salt thereof Component (H): cationic surfactant

  一种多试剂型头发处理剂，包括含有组分(A)和组分(B)的第一种组合物；以及含有组分(C)的第二种组合物，其中第二种组合物中组分(H)与组分(C)的重量比(H)/(C)小于1。 一种头发处理方法，包括以下步骤：将第一种组合物涂抹在头发上并冲洗(i)，然后将第二种组合物涂抹在头发上(ii)。 成分(A)：无机物含量为 230 或 230 以上、450 或 450 以下，有机物含量为 50 或 50 以上、250 或 250 以下的羧酸或羧酸盐。 成分（B）：阴离子表面活性剂 成分(C)：分子量为 300 或以下的芳香族磺酸或其盐 成分（H）：阳离子表面活性剂
• HAIR COSMETIC
  申请人：Kao Corporation

  公开号：EP3998060A1

  公开（公告）日：2022-05-18

  A hair cosmetic containing the following components (A) and (B), wherein a mass ratio of the component (B) to the component (A), (B)/(A), is 0.25 or more and 1.90 or less: (A) an aromatic sulfonic acid or a salt thereof having a molecular weight of 300 or less; and (B) a cationic polymer having a cationic charge density of 3.3 meq/g or more and less than 4.5 meq/g.

  一种含下列组分(A)和(B)的护发化妆品，其中组分(B)与组分(A)的质量比(B)/(A)为 0.25 或以上且 1.90 或以下： (A) 分子量为 300 或以下的芳香族磺酸或其盐；以及 (B) 阳离子电荷密度为 3.3 meq/g 或以上且小于 4.5 meq/g 的阳离子聚合物。