N-(4,6-dimethylpyrimidin-2-yl)-4-[(naphthalen-2-ylmethyl)-amino]-benzenesulfonamide | 491600-38-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(4,6-dimethylpyrimidin-2-yl)-4-[(naphthalen-2-ylmethyl)-amino]-benzenesulfonamide
• 英文别名: N-(4,6-dimethylpyrimidin-2-yl)-4-(naphthalen-2-ylmethylamino)benzenesulfonamide
• CAS: 491600-38-5
• 化学式: C₂₃H₂₂N₄O₂S
• 分子量: 418.519
• InChiKey: ABWVONCEGDACFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  92.4
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Compounds useful for treatment or prevention of disease mediated by alpha-2B-adrenoceptor
  申请人：——

  公开号：US20030073710A1

  公开（公告）日：2003-04-17

  A compound, suitable as an alpha-2B-adrenoceptor antagoist, having a structure of formula (I) 1 or a pharmaceutically acceptable salt thereof wherein R 1 , R 2 , R 3 , R 4 and R 5 are independently of each other H, a straight or branched alkyl or alkoxy group with 1 to 4 carbon atoms, or a halogen; X is H, a straight or branched alkyl chain with 1 to 4 carbon atoms, phenyl, —OH or ═O; Z is H, acetyl, —CH 2 —Ph—O—CF 3 or —CH 2 —Ph—CF 3 , Y is a ring structure optionally linked to formula (I) with an alkyl chain having one or two carbon atoms. The compound is suitable for use in a method for treatment or prevention of a disease mediated by the alpha-2B-adrenoceptor in a mammal.

  一种化合物，适用于作为α-2B-肾上腺素受体拮抗剂，其结构如式(I)1或其在药学上可接受的盐中，其中R1、R2、R3、R4和R5彼此独立地为H、具有1至4个碳原子的直链或支链烷基或烷氧基，或卤素；X为H、具有1至4个碳原子的直链或支链烷基链、苯基、—OH或═O；Z为H、乙酰基、—CH2—Ph—O—CF3或— —Ph— ，Y为一个环结构，可选择地与式(I)连接，具有一个或两个碳原子的烷基链。该化合物适用于用于治疗或预防哺乳动物体内由α-2B-肾上腺素受体介导的疾病的方法。
• COMPOUNDS USEFUL FOR TREATMENT OR PREVENTION OF DISEASE MEDIATED BY ALPHA-2B-ADRENOCEPTOR
  申请人：Oy Juvantia Pharma Ltd

  公开号：EP1417182A1

  公开（公告）日：2004-05-12
• US6767909B2
  申请人：——

  公开号：US6767909B2

  公开（公告）日：2004-07-27
• [EN] COMPOUNDS USEFUL FOR TREATMENT OR PREVENTION OF DISEASE MEDIATED BY ALPHA-2B-ADRENOCEPTOR<br/>[FR] COMPOSES UTILES POUR LE TRAITEMENT OU LA PREVENTION D'UNE MALADIE INDUITE PAR L'ALPHA-2B-ADRENORECEPTEUR
  申请人：JUVANTIA PHARMA LTD OY

  公开号：WO2003008387A1

  公开（公告）日：2003-01-30

  The invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, R4 and R5 are independently of each other H, a straight or branched alkyl or alkoxy group with 1 to 4 carbon atoms, or a halogen; X is H, a straight or branched alkyl chain with 1 to 4 carbon atoms, phenyl, -OH or =O; Z is H, acetyl, -CH2-Ph-O-CF3 or CH2-Ph-CF3, Y is a ring structure optionally linked to formula (I) with an alkyl chain having one or two carbon atoms. This invention further relates to the use of said compounds for the manufacture of a pharmaceutical preparation useful for the treatment or prevention of a disease mediated by the alpha-2B-adrenoceptor in a mammal.