N-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-N'-methyl-dibenzofuran-2,8-diamine | 350018-94-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: N-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-N'-methyl-dibenzofuran-2,8-diamine
• 英文别名: 8-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-2-N-methyldibenzofuran-2,8-diamine
• CAS: 350018-94-9
• 化学式: C₂₂H₂₀N₂O₃
• 分子量: 360.412
• InChiKey: YABUSALTDGBOBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  55.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Tricyclic compounds and method of treating herpes virus
  申请人：——

  公开号：US20030229073A1

  公开（公告）日：2003-12-11

  The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X=O, (CH 2 ) m , S, SO, SO 2 , NH, NR 8 or a chemical bond; Y=O, (CH 2 ) m , S, SO, SO 2 , NH, NR 8 ; Z=NH, O, NR 8 , S, SO, SO 2 . The remaining substituents are described in the specification.

  本发明提供了一种公式(I)的化合物及其药学上可接受的盐，对于单纯疱疹病毒家族的病毒具有有用的抗病毒活性。在该式中，X=O、(CH2)m、S、SO、SO2、NH、NR8或化学键；Y=O、( )m、S、SO、SO2、NH、NR8；Z=NH、O、NR8、S、SO、SO2。其余的取代基在说明书中描述。
• TRICYCLIC COMPOUNDS WITH ANTIVIRAL ACTIVITY
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1248777A2

  公开（公告）日：2002-10-16
• Tricyclic compounds with antiviral activity
  申请人：Booth John Richard

  公开号：US20050075332A1

  公开（公告）日：2005-04-07

  The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X═O, (CH 2 ) m , S, SO, SO 2 , NH, NR 8 , or a chemical bond; Y═O, (CH 2 ) m , S, SO, SO 2 , NH, NR 8 ; Z=NH, O, NR 8 , S, SO, SO 2 . The remaining substituents are described in the specification.
• [EN] TRICYCLIC COMPOUNDS AND METHOD OF TREATING HERPES VIRUS<br/>[FR] COMPOSES TRICYCLIQUES ET PROCEDES DE TRAITEMENT DES HERPESVIRUS
  申请人：WARNER LAMBERT CO

  公开号：WO2001051479A2

  公开（公告）日：2001-07-19

  The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X = O, (CH2)m, S, SO, SO2, NH, NR8 or a chemical bond; Y = O, (CH2)m, S, SO, SO2, NH, NR8; Z = NH, O, NR8, S, SO, SO2. The remaining substituents are described in the specification.