6,8-dichlorospiro[3H-chromene-2,4'-piperidine]-4-one | 927978-46-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6,8-dichlorospiro[3H-chromene-2,4'-piperidine]-4-one
• CAS: 927978-46-9
• 化学式: C₁₃H₁₃Cl₂NO₂
• 分子量: 286.158
• InChiKey: SIHQSABORGFHMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] SPIROCYCLIC COMPOUNDS AS STEAROYL COA DESATURASE INHIBITORS<br/>[FR] COMPOSÉS SPIROCYCLIQUES EN TANT QU'INHIBITEURS DE STÉAROYLE COA DÉSATURASE
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2009037542A2

  公开（公告）日：2009-03-26

  The present invention provides Stearoyl CoA Desaturase (SCD) inhibitors. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase 1 (SCDl). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase (SCD).