2-({[(2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl)oxy]acetyl}amino)benzoic acid | 845829-85-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-({[(2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl)oxy]acetyl}amino)benzoic acid
• 英文别名: 2-[[2-[(2,2-Dimethyl-3,4-dihydrochromen-6-yl)oxy]acetyl]amino]benzoic acid
• CAS: 845829-85-8
• 化学式: C₂₀H₂₁NO₅
• 分子量: 355.39
• InChiKey: KGPPRZXODXBMTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Anthranilic acid derivatives and their use as activators of the hm74a receptor
  申请人：Campbell Matthew

  公开号：US20070191378A1

  公开（公告）日：2007-08-16

  Therapeutically active anthranilic acid derivatives of Formula (I), processes for the preparation of said derivatives, pharmaceutical formulations containing the compounds and the use of the compounds in therapy, particularly in the treatment of diseases in which under-activation of the HM74A receptor contributes to the disease or in which activation of the receptor will be beneficial, are disclosed.

  本文披露了公式（I）的治疗活性蒽酸衍生物，制备该衍生物的过程，含有该化合物的制药配方以及化合物在治疗中的使用，特别是在治疗HM74A受体欠活化导致疾病或激活该受体将有益的疾病中的使用。
• ANTHRANILIC ACID DERIVATIVES AND THEIR USE AS ACTIVATORS OF THE HM74A RECEPTOR
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1689699A2

  公开（公告）日：2006-08-16
• [EN] ANTHRANILIC ACID DERIVATIVES AND THEIR USE AS ACTIVATORS OF THE HM74A RECEPTOR<br/>[FR] COMPOSES CHIMIQUES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2005016867A2

  公开（公告）日：2005-02-24

  Therapeutically active anthranilic acid derivatives of Formula (I) wherein R1, R2 and Z are as defined in the specification, processes for the preparation of said derivatives, pharmaceutical formulations containing the active compounds and the use of the compounds in therapy, particularly in the treatment of diseases in which under-activation of the HM74A receptor contributes to the disease or in which activation of the receptor will be beneficial, are disclosed.