(Z)-1-bromo-4-(2-phenylprop-1-en-1-yl)benzene | 1086214-83-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (Z)-1-bromo-4-(2-phenylprop-1-en-1-yl)benzene
• 英文别名: 1-bromo-4-(2-phenylprop-1-en-1-yl)benzene；(Z)-1-(4-bromophenyl)-2-phenylprop-1-ene；1-bromo-4-[(Z)-2-phenylprop-1-enyl]benzene
• CAS: 1086214-83-6
• 化学式: C₁₅H₁₃Br
• 分子量: 273.172
• InChiKey: VJZZUJPUOPZXPL-QXMHVHEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  (1-溴乙基)苯 在 lithium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 12.0h， 生成 (Z)-1-bromo-4-(2-phenylprop-1-en-1-yl)benzene 、 (E)-1-bromo-4-(2-phenylprop-1-en-1-yl)benzene
  参考文献：
  名称：

  使用水性Wittig方法合成α-甲基对苯二酚，并将其用于开发有效的人类芳香酶抑制剂。

  摘要：

  描述了使用三丙基膦衍生的salts盐合成α-甲基对苯二酚的水性Wittig方法学的发展。Wittig烯烃化反应产率高，并且可以通过简单过滤和用水洗涤来分离丁苯醚。通过高效，区域选择性地将溴化氢加到苯乙烯中来获得所使用的新型phospho盐。报道了将α-甲基对苯二酚用于合成一系列对苯二酚-三唑类，并研究了它们对CYP450 19A1（芳香酶）的抑制作用。总体结构活性概况提供了有关芳基卤化物-酮生物等位基因假说的更多证据，并确定6c为体外芳香化酶的有效抑制剂（Ki = 8 nM）。

  DOI：

  10.1016/j.bmcl.2019.03.033

文献信息

• One-Pot Intermolecular Reductive Cross-Coupling of Deactivated Aldehydes to Unsymmetrically 1,2-Disubstituted Alkenes
  作者：Anna I. Arkhypchuk、Nicolas D’Imperio、Sascha Ott

  DOI：10.1021/acs.orglett.8b01754

  日期：2018.9.7

  MesP(Li)TMS, and an aldehyde affords Mes-phosphaalkenes which, upon methanol addition and P-oxidation, react with a second carbonyl compound site specifically to produce unsymmetric alkenes. The E/Z selectivity of the one-pot cross coupling is largely determined by the electronic nature of the aryl substituent of the first aldehyde, with electron-donating groups giving rise to increased amounts of Z-alkenes.

  锂化的仲膦MesP（Li）TMS与醛之间的磷酸-彼得森反应提供了Mes-磷烯烃，在甲醇加成和P-氧化后，Mes-磷烯烃与第二个羰基化合物位点专门反应生成不对称烯烃。一锅交叉偶联的E / Z选择性在很大程度上取决于第一醛的芳基取代基的电子性质，给电子基团导致Z-烯烃的量增加。
• Iron-catalysed tandem cross-dehydrogenative coupling (CDC) of terminal allylic C(sp3) to C(sp2) of styrene and benzoannulation in the synthesis of polysubstituted naphthalenes
  作者：Hua Liu、Li Cao、Jia Sun、John S. Fossey、Wei-Ping Deng

  DOI：10.1039/c2cc17330a

  日期：——

  A novel iron-catalysed tandem cross-dehydrogenative coupling and benzoannulation process was developed for the synthesis of biologically and synthetically important polysubstituted naphthalene derivatives from simple 1,2-aryl-propenes and styrenes in moderate to good yields.

  本研究开发了一种新型铁催化串联交叉脱氢偶联和苯并氮化工艺，用于从简单的 1,2-芳基丙烯和苯乙烯合成具有重要生物和合成意义的多取代萘衍生物，产率为中等到良好。
• Electrophotographic photoreceptor and charge-transporting material for electrophotographic photoreceptor
  申请人：Kobayashi Tohru

  公开号：US20060147823A1

  公开（公告）日：2006-07-06

  A charge transporting material for use in an electrophotographic photoreceptor, which comprises a compound represented by the formula (1); and an electrophotographic photoreceptor using this charge transporting material. As the electrophotographic photoreceptor using the charge transporting material, there are illustrated, for example, a lamination type photoreceptor having a charge generating layer 2 and a charge transporting layer 3 and, as needed, an interlayer 7, and a single layer type photoreceptor. In the formula, R 1 to R 5 each independently represents a hydrogen atom, an alkyl group, a halogen atom, an alkoxy group, an aryl group or a substituted aryl group, and R 6 represents a hydrogen atom, an alkyl group, an aryl group or a substituted aryl group.

  一种用于电致发光感光器的电荷传输材料，它包括由式（1）表示的化合物；以及一种使用这种电荷传输材料的电致发光感光器。作为使用该电荷传输材料的电致发光感光元件，举例说明了一种层压式感光元件，它具有电荷发生层 2 和电荷传输层 3 以及必要的中间层 7, 和单层型光感受器。式中，R 1 至 R 5 各自独立地代表氢原子、烷基、卤素原子、烷氧基、芳基或取代的芳基，而 R 6 代表氢原子、烷基、芳基或取代的芳基。
• [EN] ELECTROPHOTOGRAPHIC PHOTORECEPTOR AND CHARGE-TRANSPORTING MATERIAL FOR ELECTROPHOTOGRAPHIC PHOTORECEPTOR<br/>[FR] PHOTORECEPTEUR ELECTROPHOTOGRAPHIQUE ET MATERIAU TRANSPORTANT UNE CHARGE DESTINE A UN PHOTORECEPTEUR ELECTROPHOTOGRAPHIQUE
  申请人：TAKASAGO PERFUMERY CO LTD

  公开号：WO2004074943A1

  公开（公告）日：2004-09-02

  A charge transporting material for use in an electrophotographic photoreceptor, which comprises a compound represented by the formula (1); and an electrophotographic photoreceptor using this charge transporting material. As the electrophotographic photoreceptor using the charge transporting material, there are illustrated, for example, a lamination type photoreceptor having a charge generating layer 2 and a charge transporting layer 3 and, as needed, an interlayer 7, and a single layer type photoreceptor. In the formula, R1 to R5 each independently represents a hydrogen atom, an alkyl group, a halogen atom, an alkoxy group, an aryl group or a substituted aryl group, and R6 represents a hydrogen atom, an alkyl group, an aryl group or a substituted aryl group.