N-(prop-2-yn-1-yl)-N-(3-(triethoxysilyl)propyl)prop-2-yn-1-amine | 1332499-37-2

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: N-(prop-2-yn-1-yl)-N-(3-(triethoxysilyl)propyl)prop-2-yn-1-amine
• 英文别名: N-(prop-2-ynyl)-N-(3-(triethoxysilyl)propyl)prop-2-yn-1-amine；(3-di(prop-2-yn-1-yl)aminopropyl)triethoxysilane；N,N-bis(prop-2-ynyl)-3-triethoxysilylpropan-1-amine
• CAS: 1332499-37-2
• 化学式: C₁₅H₂₇NO₃Si
• 分子量: 297.47
• InChiKey: BZKYLRWKJZFTGP-UHFFFAOYSA-N

物化性质

• 沸点：
  332.1±27.0 °C(Predicted)
• 密度：
  0.972±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.99
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(prop-2-yn-1-yl)-N-(3-(triethoxysilyl)propyl)prop-2-yn-1-amine 、 2-azidoethylphosphonic acid diethyl ester 在 溴化三(三苯基磷)铜 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.08h， 以91%的产率得到N,N-bis[[1-(2-diethoxyphosphorylethyl)triazol-4-yl]methyl]-3-triethoxysilylpropan-1-amine
  参考文献：
  名称：

  Click Approaches to Functional Water-Sensitive Organotriethoxysilanes

  摘要：

  The derivatization of functional organic fragments with triethoxysilyl groups to afford hydrolyzable organosilanes with targeted properties using the copper-catalyzed alkyne azide cydoaddition reaction under strictly anhydrous conditions is described according to two approaches, starting from five silylated substrates. This high yield, fast, and selective method is applicable to a wide range of substrates and is expected to lead to important achievements in the field of functional hybrid silica.

  DOI：

  10.1021/jo201484n
• 作为产物：
  描述：

  3-氨基丙基三乙氧基硅烷 、 3-溴丙炔 在 calcium hydride 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 12.0h， 以85%的产率得到N-(prop-2-yn-1-yl)-N-(3-(triethoxysilyl)propyl)prop-2-yn-1-amine
  参考文献：
  名称：

  新型叠氮化炔键合反应的多功能杂二烯丙基醚单体作为交联剂在保护涂料中的应用

  摘要：

  具有交联能力的官能化杂化单体由于与其他乙烯基族单体一起使用具有灵活性，因此可以提供优于其他单体的优势。叠氮化物炔的点击反应是将三唑部分引入分子的简便方法，并且通过叠氮化物和炔化合物的适当设计，开辟了增加更多官能度的可能性。在本研究中，我们报告了含有烯丙基醚官能团（3-（2-叠氮基乙氧基）丙-1-烯）的新型叠氮化物点击连接剂的合成和使用，作为与硅氧烷官能化的二炔进行点击反应的第一个例子。新型三唑，硅氧烷官能化的二烯丙基醚（TSDE）单体。合成的TSDE，叠氮化物点击连接基和其他化合物的化学结构通过FT-IR，1 H NMR，13 C NMR和ESI-MS技术。通过FTIR，XRD，SEM，UTM，WCA，DSC和TGA对TSDE与甲基丙烯酸甲酯（MMA）的混合涂层的化学结构，形态，润湿性，拉伸和热性能进行了评估。EPS和雾化测试的实验结果表明，与PMMA相比，新合成的新型Poly（MMA-c

  DOI：

  10.1016/j.polymer.2015.02.017

文献信息

• Synthesis of trisaccharide-coated magnetic nanoparticles for antibody removal
  作者：Shuaihu Yan、Cuixia Zhao、Qidong Ren、Xinni Xie、Feng Yang、Yuguo Du

  DOI：10.1016/j.tet.2017.04.003

  日期：2017.5

  An efficient strategy for the synthesis of blood group A trisaccharide antigen has been developed. Magnetic nanoparticles having Fe3O4-Silica core-shell structure were prepared and functionalized with the prepared blood group A trisaccharide antigen derivative, and its excellent removal ability toward anti-A antibody was explored.

  已经开发了合成血型A三糖抗原的有效策略。制备具有Fe 3 O 4-二氧化硅核-壳结构的磁性纳米颗粒，并用所制备的A血型三糖抗原衍生物对其进行功能化，并探索了其对抗A抗体的优异去除能力。
• Synthesis of Neu5Ac-α-C-galactopyranosyl-functionalized magnetic nanoparticles via click chemistry
  作者：Chaoli Zhang、Xing Ma、Yuguo Du

  DOI：10.1016/j.tet.2013.06.086

  日期：2013.9

  A new type of glyco-nanoparticle has been accomplished through Cu(I)-catalyzed 1,3-dipolar cycloaddition of 6-azidohexyl Neu5Ac-alpha-C-galactoside and N-propargyl derivative, which was attached on a silica-wrapping magnetic nanoparticle. Neu5Ac-alpha-C-galactoside was stereo-selectively synthesized in 11 steps from isopropyl thiogalactopyranoside and per-acetylated Neu5Ac phenylsulfone using samarium-mediated reductive desulfonylation as the key step. Magnetic nanoparticles were prepared with one-step hydrothermal method and a subsequent coating with (N,N'-di-propargyl-3-aminopropyol) triethoxysilane derivative. (C) 2013 Elsevier Ltd. All rights reserved.
• Colloidal stability and photophysical characteristics of luminesent silica nanoparticles modified with various nitrogen/oxygen-containing trialkoxysilanes
  作者：V. A. Burilov、A. T. Latypova、R. A. Safiullin、I. S. Antipin

  DOI：10.1134/s1070363216030245

  日期：2016.3

  Surface modification of the luminescent silica nanoparticles doped with Tb(III)-p-sulfonatothiacalix[4]arene complex was carried out using a series of nitrogen/oxygen-containing trialkoxysilanes. It was found that groups capable of nonspecific interactions on the surface of the nanoparticles cause a significant decrease in their colloidal stability. The chromophore moieties in the modifiers were found to quench the luminescence of the nanoparticles. The surface modification of the nanoparticles is responsible for the change in the mechanism of luminescence quenching in the presence of copper(II) ions due to decreased accessibility of luminophores to the quencher.