1-benzyl-3-butyl-piperidine-4-one | 373604-10-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-benzyl-3-butyl-piperidine-4-one
• 英文别名: 1-benzyl-3-butylpiperidin-4-one
• CAS: 373604-10-5
• 化学式: C₁₆H₂₃NO
• 分子量: 245.365
• InChiKey: WIULZYQPJULSBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-benzyl-3-butyl-piperidine-4-one 在 potassium carbonate 作用下， 以 乙醇 、 丙酮 为溶剂， 反应 6.0h， 生成 3-butyl-1-(3-methoxy-5-(trifluoromethyl)phenyl)piperidin-4-one
  参考文献：
  名称：

  1,3-Disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors

  摘要：

  In a search for novel DPP-IV inhibitors, 2-aminobenzo[a]quinolizines were identified as submicromolar HTS hits. Due to the difficult synthetic access to this compound class, 1,3-disubstituted 4-aminopiperidines were used as model compounds for optimization. The developed synthetic methodology and the SAR could be transferred to the 2-aminobenzo[a]quinolizine series, leading to highly active DPP-IV inhibitors.

  DOI：

  10.1016/j.bmcl.2007.03.072
• 作为产物：
  描述：

  methyl 1-benzyl-3-butyl-4-oxopiperidine-3-carboxylate 在 盐酸 作用下， 以 水 为溶剂， 反应 24.0h， 以96%的产率得到1-benzyl-3-butyl-piperidine-4-one
  参考文献：
  名称：

  [EN] OXASPIRO [2.5] OCTANE DERIVATIVES AND ANALOGS
  [FR] DÉRIVÉS D'OXASPIRO[2.5]OCTANE ET ANALOGUES

  摘要：

  这项发明提供了氧杂螺[2.5]辛烷衍生物和类似物，其制备方法，中间体，药物组合物以及在治疗各种疾病和状况中的用途，例如超重和肥胖。

  公开号：

  WO2012122264A1

文献信息

• 4-Aminopiperidine derivatives
  申请人：Boehringer Markus

  公开号：US20060135561A1

  公开（公告）日：2006-06-22

  The present invention relates to compounds of the formula (I) wherein R 1 and R 2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, non-insulin dependent diabetes mellitus and/or impaired glucose tolerance, obesity, and/or metabolic syndrome or β-cell protection.

  本发明涉及如下式（I）的化合物，其中R1和R2如描述和权利要求中所定义，并且其药学上可接受的盐。这些化合物可用于治疗和/或预防与DPP-IV相关的疾病，如糖尿病、非胰岛素依赖型糖尿病和/或糖耐量受损、肥胖和/或代谢综合征或β-细胞保护。
• Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
  申请人：WOCKHARDT RESEARCH CENTER

  公开号：US20020165227A1

  公开（公告）日：2002-11-07

  The present invention relates to optically pure 8-(substituted piperidino)-benzo[i,j]quinolizines, their isomers, derivatives, salts, pseudopolymorphs, polymorphs prodrugs and hydrates thereof, to processes for their preparation, and to pharmaceutical compositions comprising 8-(substituted piperidino)-benzo[i,j]quinolizines their isomers, derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof. These compounds and compositions possess potent activity in treating local and systemic infections, particularly infections caused by sensitive and resistant Gram-positive organism infections, Gram-negative organism infections, mycobacterial infections and nosocomial pathogens, and particularly those belonging to the staphylococcus, streptococcus and enterococcus groups. Methods for treating the diseases and disorders arising from the foregoing infections in humans and animals are described by administering the compounds of the invention to said humans and animals.

  本发明涉及光学纯的8-(取代哌啶基)-苯[i,j]喹啉，它们的异构体、衍生物、盐、伪多晶体、多晶体、前药和水合物，以及它们的制备方法和包含8-(取代哌啶基)-苯[i,j]喹啉、它们的异构体、衍生物、盐、伪多晶体、多晶体和水合物的药物组合物。这些化合物和组合物在治疗局部和全身感染方面具有强效活性，特别是对敏感和耐药革兰氏阳性菌感染、革兰氏阴性菌感染、分枝杆菌感染和医院感染病原体，特别是属于葡萄球菌、链球菌和肠球菌群的感染具有活性。通过将本发明的化合物用于人类和动物治疗上述感染引起的疾病和疾病的方法也被描述。
• Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
  申请人：Wockhardt Limited

  公开号：US06608078B2

  公开（公告）日：2003-08-19

  The present invention relates to optically pure 8-(substituted piperidino)-benzo[i,j]quinolizines, their isomers, derivatives, salts, pseudopolymorphs, polymorphs prodrugs and hydrates thereof, to processes for their preparation, and to pharmaceutical compositions comprising 8-(substituted piperidino)-benzo[i,j]quinolizines their isomers, derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof. These compounds and compositions possess potent activity in treating local and systemic infections, particularly infections caused by sensitive and resistant Gram-positive organism infections, Gram-negative organism infections, mycobacterial infections and nosocomial pathogens, and particularly those belonging to the staphylococcus, streptococcus and enterococcus groups. Methods for treating the diseases and disorders arising from the foregoing infections in humans and animals are described by administering the compounds of the invention to said humans and animals.

  本发明涉及光学纯的8-（取代哌啶基）-苯并[i,j]喹啉，它们的异构体，衍生物，盐，伪多型，多型前药和水合物，以及它们的制备过程，以及包括8-（取代哌啶基）-苯并[i,j]喹啉，它们的异构体，衍生物，盐，伪多型，多型和水合物的制药组合物。这些化合物和组合物具有在治疗局部和全身感染方面的强效活性，特别是对于由敏感和耐药革兰氏阳性菌感染，革兰氏阴性菌感染，分枝杆菌感染和医院感染病原体引起的感染，特别是属于葡萄球菌，链球菌和肠球菌群的感染。通过将本发明的化合物用于人类和动物，可以描述用于治疗由上述感染引起的疾病和疾病的方法。
• 4-AMINOPIPERIDINE DERIVATIVES
  申请人：Boehringer Markus

  公开号：US20100087485A1

  公开（公告）日：2010-04-08

  The present invention relates to compounds of the formula (I) wherein R 1 and R 2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, non-insulin dependent diabetes mellitus and/or impaired glucose tolerance, obesity, and/or metabolic syndrome or β-cell protection.

  本发明涉及式(I)的化合物，其中R1和R2如描述和要求中所定义，并且其药学上可接受的盐。这些化合物可用于治疗和/或预防与DPP-IV相关的疾病，例如糖尿病、非胰岛素依赖性糖尿病和/或糖耐量受损、肥胖症和/或代谢综合征或β细胞保护。
• Oxaspiro[2.5]Octane Derivatives and Analogs
  申请人：Vath James E.

  公开号：US20150045427A1

  公开（公告）日：2015-02-12

  The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.

  本发明提供了氧杂螺[2.5]辛烷衍生物和类似物，其制备方法，中间体，制药组合物以及在治疗各种疾病和病况（例如超重和肥胖）中的应用。