4-Amino-naphthalin-1-sulfonsaeure-hydrazid | 110062-58-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-Amino-naphthalin-1-sulfonsaeure-hydrazid
• 英文别名: 4-Aminonaphthalene-1-sulfonohydrazide
• CAS: 110062-58-3
• 化学式: C₁₀H₁₁N₃O₂S
• 分子量: 237.282
• InChiKey: GRQOFFOZXMJWAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] DETECTION OF CHOLESTEROL OZONATION PRODUCTS<br/>[FR] DETECTION DE PRODUITS D'OZONATION DU CHOLESTEROL
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2005023831A1

  公开（公告）日：2005-03-17

  The invention relates to detection of cholesterol ozonation products that are generated by atherosclerotic plaque material, and to methods of detecting vascular conditions that relate to the accumulation and oxidation of cholesterol.

  这项发明涉及检测由动脉粥样硬化斑块材料产生的胆固醇臭氧化产物，以及检测与胆固醇积聚和氧化有关的血管状况的方法。
• Dihydropyrancarboxamides and uses thereof
  申请人：——

  公开号：US20040059138A1

  公开（公告）日：2004-03-25

  The present invention provides novel dihydropyrancarboxamide compounds of formula (I): 1 and collections of these compounds, and provides methods for the synthesis of these compounds; wherein R 1 -R 6 are as defined herein. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as proliferative diseases, and cancer, to name a few.

  本发明提供了式（I）的新颖二氢吡喃羧酰胺化合物： 1 以及这些化合物的集合，并提供了合成这些化合物的方法；其中R 1 -R 6 如本文所定义。此外，本发明提供了用于治疗增殖性疾病和癌症等疾病的药物组合物和方法。
• [EN] METHODS FOR THE SITE-SELECTIVE COUPLING OF A FIRST AGENT TO A SECOND AGENT<br/>[FR] PROCÉDÉS DE COUPLAGE SITE-SÉLECTIF D'UN PREMIER AGENT À UN DEUXIÈME AGENT
  申请人：UNIV GENT

  公开号：WO2017001204A1

  公开（公告）日：2017-01-05

  The present invention relates to a method for site-selective coupling of a first agent to a second agent, comprising the steps of: contacting a first agent comprising at least one furan moiety with an activation signal and with a second agent comprising at least one hydrazine moiety or at least one hydroxylamine moiety, thereby activating said furan moiety to an activated furan moiety; and reacting said activated furan moiety with the hydrazine moiety or the hydroxylamine moiety, thereby site-selectively coupling said first agent to said second agent.

  本发明涉及一种用于将第一试剂与第二试剂进行位点选择性偶联的方法，包括以下步骤：将至少含有一个呋喃基团的第一试剂与激活信号和至少含有一个肼基团或至少含有一个羟胺基团的第二试剂接触，从而将该呋喃基团激活为活化的呋喃基团；并将该活化的呋喃基团与肼基团或羟胺基团反应，从而将该第一试剂与该第二试剂进行位点选择性偶联。
• Preparation and uses of locked-ring sugar C-glycoside derivatives
  申请人：Price Neil P.

  公开号：US20080081905A1

  公开（公告）日：2008-04-03

  “Locked-ring” C-glycoside derivatives may be prepared wherein the ring of the sugar molecule remains intact without the need for any protecting groups. These C-glycoside derivatives may be produced by first reacting an aldose reducing sugar, which may be a hexose or a pentose, with a β-diketone to form a C-glycoside ketone. The C-glycoside ketone is then reacted with a ketone reactive compound, such as a hydrazine or hydroxylamine, optionally linked to a detectable label, to form a C-glycoside derivative wherein the ketone reactive compound is conjugated to the C-glycoside at the site of the ketone. The aldose reducing sugar used in the first reaction may a simple pentose or hexose monosaccharide, or it may be optionally substituted.

  可以制备“锁定环”C-糖苷衍生物，其中糖分子的环保持完整，无需任何保护基团。这些C-糖苷衍生物可以通过首先将醛糖还原糖（可以是己糖或戊糖）与β-二酮反应以形成C-糖苷酮。然后，将C-糖苷酮与酮反应性化合物（如肼或羟胺，可选地连接到可检测的标记）反应，形成一个C-糖苷衍生物，其中酮反应性化合物与C-糖苷在酮的位置结合。在第一反应中使用的醛糖还原糖可以是简单的戊糖或己糖单糖，也可以是可选择地取代的。
• [EN] COMPOUNDS AND SENSOR FOR DETECION OF POLYCYCLIC AROMATIC HYDROCARBONS<br/>[FR] COMPOSES ET CAPTEURS DESTINES A LA DETECTION D'HYDROCARBURES AROMATIQUES POLYCYCLIQUES
  申请人：CENTRAL SCIENCE LAB CSL

  公开号：WO2005090379A1

  公开（公告）日：2005-09-29

  Compound for binding an electron deficient polycyclic aromatic hydrocarbon (PAH) comprising a 'tweezer' of formula I: wherein is any C15-45 planar skeleton comprised of a saturated fused alicyclic (3) to (8) ring system each X is a linking group; and each is a group Ar substituted by a total of from (1) up to 20 halogen atoms each n is a whole number integer from (1) to (3) and the sum of n is (2) to (6); A is a group or moiety selected from lipophilic groups such as C4-20 aliphatic or alicyclic saturated or unsaturated hydrocarbon groups; T is an optional support or detection element and m is (0) or (1); and k is (0) or is a whole number integer selected from (1) to (3); wherein the groups Ar are pendant to at least two different rings of the planar B skeleton and are located on the same face of the planar B skeleton forming, together with B, a pocket suitable for receiving and binding a guest PAH species; a process for the preparation thereof; a polymer comprising immobilised compound of formula I and method for the preparation thereof; a method for detecting a PAH using a compound of formula I; a PAH sensor comprising a compound of formula I; method for PAH detection therewith; and uses thereof.

  用于结合电子不足多环芳烃（PAH）的化合物，包括公式I中的“镊子”：其中任何C15-45平面骨架由饱和融合脂环（3）到（8）环系统组成，每个X是连接基团；每个是由总共（1）到（20）个卤原子取代的Ar基团，每个n是从（1）到（3）的整数，n的总和为（2）到（6）；A是从疏水基团中选择的基团或基团，例如C4-20脂肪或脂环饱和或不饱和碳氢基团；T是可选的支持或检测元素，m为（0）或（1）；k为（0）或从（1）到（3）中选择的整数；其中基团Ar挂接到平面B骨架的至少两个不同环上，并位于平面B骨架的同一面上，与B一起形成一个适用于接收和结合宿主PAH物种的口袋；其制备方法；包含公式I固定化合物的聚合物及其制备方法；使用公式I化合物检测PAH的方法；包含公式I化合物的PAH传感器；用于PAH检测的方法；以及其用途。