cyclopentyl (2S)-2-[[1-[5-(hydroxycarbamoyl)pyrimidin-2-yl]piperidin-4-yl]methylamino]-2-naphthalen-1-ylacetate | 1022928-39-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: cyclopentyl (2S)-2-[[1-[5-(hydroxycarbamoyl)pyrimidin-2-yl]piperidin-4-yl]methylamino]-2-naphthalen-1-ylacetate
• CAS: 1022928-39-7
• 化学式: C₂₈H₃₃N₅O₄
• 分子量: 503.601
• InChiKey: ZRBANDMVDBCRQJ-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE
  申请人：Moffat David Festus Charles

  公开号：US20100317678A1

  公开（公告）日：2010-12-16

  Compounds of formula (I), and salts, N-oxides, hydrates and solvates thereof are histone deacetylase inhibitors and are useful in the treatment of cell proliferative diseases, including cancers: wherein Q, V and W independently represent —N═ or —C═; B is a divalent radical selected from (B1), (B2), (B3), (B4), (B5) and (B6). wherein the bond marked * is linked to the ring containing Q, V and W through -[Linker1]- and the bond marked ** is linked to A through -[Linker2]-; A is an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system; -[Linker1]- and -[Linker2]- independently represent a bond, or a divalent linker radical; and R is (a) a radical of formula R 1 R 2 CHNH—Y-L 1 -X 1 —(CH 2 ) z — or (b) a radical of formula R-L 1 -Y 1 —(CH 2 ) z —,
• US8962825B2
  申请人：——

  公开号：US8962825B2

  公开（公告）日：2015-02-24