N-Ethyl-N'-cyclohexyl-piperazin | 24426-39-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-Ethyl-N'-cyclohexyl-piperazin
• 英文别名: 1-Cyclohexyl-4-ethylpiperazine
• CAS: 24426-39-9
• 化学式: C₁₂H₂₄N₂
• 分子量: 196.336
• InChiKey: LZUHHDDJFZHXAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-乙基哌嗪 、 环己醇 在 potassium dihydrogenphosphate 、 horse liver alcohol dehydrogenase 、 sodium cyanoborohydride 、 C₁₂₈H₁₀₈N₂₈O₁₂Zn₄⁽⁸⁺⁾*8BF₄^(1-) 、 三乙胺 作用下， 以 水 、 乙腈 为溶剂， 以21%的产率得到N-Ethyl-N'-cyclohexyl-piperazin
  参考文献：
  名称：

  Enzyme Grafting with a Cofactor-Decorated Metal-Organic Capsule for Solar-to-Chemical Conversion

  摘要：

  DOI：

  10.1021/jacs.2c12636

文献信息

• Process for Isomerization of CIS-2-Pentenenitrile to 3-Pentenenitriles
  申请人：BASF SE

  公开号：US20130289299A1

  公开（公告）日：2013-10-31

  The present invention relates to an improved process for batchwise or continuous isomerization of cis-2-pentenenitrile to 3-pentenenitriles in the presence of 1,4-diazabicyclo[2.2.2]octane as catalyst.

  本发明涉及在1,4-二氮杂双环[2.2.2]辛烷存在下，对顺-2-戊烯腈进行批量或连续异构化改进过程，以得到3-戊烯腈。
• Indenoisoquinolinone Analogs and Methods of Use Thereof
  申请人：JAGTAP Prakash

  公开号：US20100004220A1

  公开（公告）日：2010-01-07

  The present invention relates to Indenoisoquinolinone Analogs, compositions comprising an effective amount of an Indenoisoquinolinone Analog and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, neuropathy, erectile dysfunction or urinary incontinence, comprising administering to a subject in need thereof an effective amount of an Indenoisoquinolinone Analog.

  本发明涉及Indenoisoquinolinone类似物，包括有效量的Indenoisoquinolinone类似物组成的组合物，以及用于治疗或预防炎症性疾病、再灌注损伤、糖尿病、糖尿病并发症、器官移植引起的再氧化损伤、缺血状况、神经退行性疾病、肾功能衰竭、血管疾病、心血管疾病、癌症、早产并发症、心肌病、视网膜病变、肾病、神经病变、勃起功能障碍或尿失禁的方法，包括向需要的受体中注射有效量的Indenoisoquinolinone类似物。
• PHTHALAZINONE DERIVATIVES
  申请人：Menear Keith Allan

  公开号：US20080280910A1

  公开（公告）日：2008-11-13

  A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring or an optionally substituted, fused cyclohexene ring; D is selected from: where Y 1 is selected from CH and N, Y 2 is selected from CH and N, Y 3 is selected from CH, CF and N and Y 4 is selected from CH and N; where Y 1 is selected from CH and N and Y 2 is selected from CH and N; where Q is O or S; and where Q is O or S; and R D is an optionally substituted C 5-20 aryl group, bound to D by a carbon-carbon bond.

  化合物的公式(I)如下：其中：A和B一起表示一个可选择取代的融合芳香环或一个可选择取代的融合环己烯环；D从以下选取：其中Y1从CH和N中选取，Y2从CH和N中选取，Y3从CH、CF和N中选取，Y4从CH和N中选取；其中Y1从CH和N中选取，Y2从CH和N中选取；其中Q为O或S；且其中Q为O或S；RDis一个可选择取代的C5-20芳基基团，通过碳-碳键与D结合。
• INDENOISOQUINOLINONE ANALOGS AND METHODS OF USE THEREOF
  申请人：Jagtap Prakash

  公开号：US20100121049A1

  公开（公告）日：2010-05-13

  The present invention relates to Indenoisoquinolinone Analogs, compositions comprising an effective amount of an Indenoisoquinolinone Analog and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, neuropathy, erectile dysfunction or urinary incontinence, comprising administering to a subject in need thereof an effective amount of an Indenoisoquinolinone Analog.

  本发明涉及吲哚异喹啉衍生物，包括含有效量的吲哚异喹啉衍生物的组合物及其用于治疗或预防炎症性疾病、再灌注损伤、糖尿病、糖尿病并发症、器官移植所致的再氧化损伤、缺血症、神经退行性疾病、肾衰竭、血管疾病、心血管疾病、癌症、早产并发症、心肌病、视网膜病、肾病、神经病变、勃起功能障碍或尿失禁的方法，包括向需要治疗的受体中投与有效量的吲哚异喹啉衍生物。
• SUBSTITUTED TETRACYCLIC 1H-INDENO [1,2-B]PYRIDINE-2(5H)-ONE ANALOGS THEREOF AND USES THEREOF
  申请人：JAGTAP Prakash

  公开号：US20100261706A1

  公开（公告）日：2010-10-14

  Provided herein are tetracyclic 1H-indeno[1,2-b]pyridine-2(5H)-one analogs and derivatives, compositions comprising an effective amount of a tetracyclic 1H-indeno[1,2-b]pyridine-2(5H)-one analog and/or derivative and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, a reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, an ocular or opthalmologic disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, contrast induced nephropathy, neuropathy, erectile dysfunction or urinary incontinence, comprising administering to a subject in need thereof an effective amount of a tetracyclic 1H-indeno[1,2-b]pyridine-2(5H)-one analog or derivative.

  本文提供四环1H-吲哚[1,2-b]吡啶-2(5H)-酮类似物和衍生物，包括含有效量四环1H-吲哚[1,2-b]吡啶-2(5H)-酮类似物和/或衍生物的组合物以及治疗或预防炎症性疾病、再灌注损伤、糖尿病、糖尿病并发症、器官移植引起的再氧化损伤、缺血症、神经退行性疾病、肾功能衰竭、血管疾病、心血管疾病、眼部或眼科疾病、癌症、早产并发症、心肌病、视网膜病、肾病、造影剂诱导性肾病、神经病和勃起功能障碍或尿失禁的方法，包括向需要的受体施用有效量的四环1H-吲哚[1,2-b]吡啶-2(5H)-酮类似物或衍生物。