N-(3-pyrrolidin-1-ylpropyl)-9H-dipyrido[2,3-b:4',3'-f]pyrimido[4,5-d]azepin-2-amine | 1246546-77-9

分子结构分类

有机化合物 - 有机杂环化合物 - 吡咯并吡啶类

中文名称

——

中文别名

——

英文名称

N-(3-pyrrolidin-1-ylpropyl)-9H-dipyrido[2,3-b:4',3'-f]pyrimido[4,5-d]azepin-2-amine

英文别名

N-(3-pyrrolidin-1-ylpropyl)-3,5,11,14,16-pentazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),2,4,6,8(13),9,11,16,18-nonaen-4-amine

N-(3-pyrrolidin-1-ylpropyl)-9H-dipyrido[2,3-b:4',3'-f]pyrimido[4,5-d]azepin-2-amine化学式

CAS

1246546-77-9

化学式

C₂₁H₂₃N₇

mdl

——

分子量

373.461

InChiKey

BOYQGRFJWDMHJD-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

3
重原子数：

28
可旋转键数：

5
环数：

5.0
sp3杂化的碳原子比例：

0.33
拓扑面积：

78.9
氢给体数：

2
氢受体数：

7

文献信息

SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS

申请人：Tandon Manish

公开号：US20100249108A1

公开（公告）日：2010-09-30

The present invention relates to substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

本发明涉及取代的二吡咯-嘧啶-二氮杂环化合物，取代的苯并-二吡咯-嘧啶-二氮杂环化合物以及合成这些化合物的方法。本发明还涉及含有取代的二吡咯-嘧啶-二氮杂环化合物，取代的苯并-二吡咯-嘧啶-二氮杂环化合物的药物组合物，并通过将这些化合物和药物组合物给予需要的受体中，治疗细胞增殖性疾病，如癌症的方法。
US8349827B2

申请人：——

公开号：US8349827B2

公开（公告）日：2013-01-08
[EN] SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS<br/>[FR] COMPOSÉS DIPYRIDO-PYRIMIDO-DIAZÉPINE ET BENZO-PYRIDO-PYRIMIDO SUBSTITUÉS

申请人：ARQULE INC

公开号：WO2010114898A1

公开（公告）日：2010-10-07

The present invention relates to substituted dipyrido-pyrimido-diazepine compounds of formula (I), substituted benzo-pyrido-pyrimido-diazepine compounds of formula (I) and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido- diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

同类化合物

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N-(3-pyrrolidin-1-ylpropyl)-9H-dipyrido[2,3-b:4',3'-f]pyrimido[4,5-d]azepin-2-amine | 1246546-77-9

分子结构分类

计算性质

文献信息

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