(1-bromonaphthalen-2-yl)methyl amidinoisothiourea hydrochloride | 1211527-92-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (1-bromonaphthalen-2-yl)methyl amidinoisothiourea hydrochloride
• 英文别名: (1-bromonaphthalen-2-yl)methyl N-(diaminomethylidene)carbamimidothioate;hydrochloride
• CAS: 1211527-92-2
• 化学式: C₁₃H₁₃BrN₄S*ClH
• 分子量: 373.704
• InChiKey: GTUGXCJQNSJCAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.68
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  114
• 氢给体数：
  4
• 氢受体数：
  2

文献信息

• INHIBITION OF CELL PROLIFERATION
  申请人：Sebti Said M.

  公开号：US20100184851A1

  公开（公告）日：2010-07-22

  Compounds of formula (I) and (II) are provided as modulators of Rb:Raf-1 interactions which are potent, selective disruptors of Rb:Raf-1 binding. Therapeutic methods of using the compounds, for example for treating or ameliorating a cell proliferation disorder such as cancer, are provided.
• [EN] INHIBITION OF CELL PROLIFERATION<br/>[FR] INHIBITION DE LA PROLIFÉRATION CELLULAIRE
  申请人：UNIV SOUTH FLORIDA

  公开号：WO2010025448A2

  公开（公告）日：2010-03-04

  Compounds of formula (I) and (II) are provided as modulators of Rb:Raf-1 interactions which are potent, selective disruptors of Rb:Raf-1 binding. Therapeutic methods of using the compounds, for example for treating or ameliorating a cell proliferation disorder such as cancer, are provided.