2-methoxy-N-(5H-γ-carbolin-8-yl)naphthalene-1-sulfonamide | 1158627-83-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-methoxy-N-(5H-γ-carbolin-8-yl)naphthalene-1-sulfonamide
• 英文别名: 2-methoxy-N-(5H-pyrido[4,3-b]indol-8-yl)naphthalene-1-sulfonamide
• CAS: 1158627-83-8
• 化学式: C₂₂H₁₇N₃O₃S
• 分子量: 403.461
• InChiKey: OUISZMQVQZVXEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  92.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  tert-butyl 8-((2-methoxynaphthalene)-1-sulfonamido)-5H-pyrido[4,3-b]indole-5-carboxylate 在 盐酸 、 水 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 12.0h， 生成 2-methoxy-N-(5H-γ-carbolin-8-yl)naphthalene-1-sulfonamide
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel N-γ-carboline arylsulfonamides as anticancer agents

  摘要：

  A series of novel N-gamma-carboline arylsulfonamide derivatives designed based on the common feature of colchicine binding site inhibitors were synthesized and evaluated for their antiproliferative activity in vitro against five human cancer cell lines. Most of the compounds showed moderate to potent cytotoxic activities against all the tested cells. Preliminary mechanism research on one of the most potent compound 6p indicated that it was a potent tubulin polymerization inhibitor, with IC50 value of 3.8 mu M, equivalent to that of CA-4, and arresting cell cycle in G(2)/M phase. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.10.047

文献信息

• Design, synthesis, and biological evaluation of novel N-γ-carboline arylsulfonamides as anticancer agents
  作者：Jing Chen、Tao Liu、Rui Wu、Jianshu Lou、Ji Cao、Xiaowu Dong、Bo Yang、Qiaojun He、Yongzhou Hu

  DOI：10.1016/j.bmc.2010.10.047

  日期：2010.12

  A series of novel N-gamma-carboline arylsulfonamide derivatives designed based on the common feature of colchicine binding site inhibitors were synthesized and evaluated for their antiproliferative activity in vitro against five human cancer cell lines. Most of the compounds showed moderate to potent cytotoxic activities against all the tested cells. Preliminary mechanism research on one of the most potent compound 6p indicated that it was a potent tubulin polymerization inhibitor, with IC50 value of 3.8 mu M, equivalent to that of CA-4, and arresting cell cycle in G(2)/M phase. (C) 2010 Elsevier Ltd. All rights reserved.