9-tert.Butyl-6-demethyl-6-deoxytetracyclin | 53173-80-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 四环素类
• 英文名称: 9-tert.Butyl-6-demethyl-6-deoxytetracyclin
• 英文别名: 9-t-Butyl-6-demethyl-6-deoxytetralin
• CAS: 53173-80-1
• 化学式: C₂₅H₃₀N₂O₇
• 分子量: 470.522
• InChiKey: PKCANADISGBHER-JOUBUWRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.42
• 重原子数：
  34.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  161.39
• 氢给体数：
  5.0
• 氢受体数：
  8.0

文献信息

• Amino-methyl substituted tetracycline compounds
  申请人：Nelson L. Mark

  公开号：US20080015169A1

  公开（公告）日：2008-01-17

  Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
• 9-Aminomethyl Substituted Minocycline Compounds
  申请人：Nelson Mark L.

  公开号：US20100113400A1

  公开（公告）日：2010-05-06

  The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
• 9-AMINOMETHYL SUBSTITUTED MINOCYCLINE COMPOUNDS
  申请人：Paratek Pharmaceuticals, Inc.

  公开号：US20140309199A1

  公开（公告）日：2014-10-16

  The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
• US7326696B2
  申请人：——

  公开号：US7326696B2

  公开（公告）日：2008-02-05
• US7553828B2
  申请人：——

  公开号：US7553828B2

  公开（公告）日：2009-06-30