8-(benzenesulfonylmethyl)-4,5-dihydro-3,6-dioxabenzo[e]azulene-7-carboxylic | 1356110-73-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 8-(benzenesulfonylmethyl)-4,5-dihydro-3,6-dioxabenzo[e]azulene-7-carboxylic
• 英文别名: 8-(Benzenesulfonylmethyl)-4,5-dihydrofuro[2,3-d][1]benzoxepine-7-carboxylic acid
• CAS: 1356110-73-0
• 化学式: C₂₀H₁₆O₆S
• 分子量: 384.409
• InChiKey: BRPFFWNUJBVZEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME<br/>[FR] COMPOSÉS TRICYCLIQUES ET PROCÉDÉS POUR LES PRÉPARER ET LES UTILISER
  申请人：ZAFGEN CORP

  公开号：WO2012012642A1

  公开（公告）日：2012-01-26

  The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

  该发明提供了三环化合物及其在治疗医学疾病（如肥胖症）中的用途。提供了制备各种三环化合物的药物组合物和方法。这些化合物被认为具有对蛋氨酸氨肽酶2的活性。
• Tricyclic Compounds and Methods of Making and Using Same
  申请人：Clark David

  公开号：US20130123235A1

  公开（公告）日：2013-05-16

  The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

  本发明提供三环化合物及其在治疗医学障碍（如肥胖症）中的应用。还提供了制备各种三环化合物的制药组合物和方法。这些化合物被认为具有对甲硫氨酰基氨肽酶2的活性。
• TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME
  申请人：Zafgen, Inc.

  公开号：EP2595988A1

  公开（公告）日：2013-05-29
• TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
  申请人：Zafgen, Inc.

  公开号：US20160354338A1

  公开（公告）日：2016-12-08

  The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
• US9266896B2
  申请人：——

  公开号：US9266896B2

  公开（公告）日：2016-02-23