| 1454705-77-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1454705-77-1
• 化学式: C₁₅H₁₄O₃S
• 分子量: 274.34
• InChiKey: NMVWYVRQYNHXQX-UHFFFAOYSA-N

物化性质

• 沸点：
  433.0±30.0 °C(predicted)
• 密度：
  1.235±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  、 2-氨基二苯甲酮 在 aluminum (III) chloride 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以80%的产率得到methyl 2-[2-(2-naphthyl)-4-phenyl-3-quinolyl]sulfanylacetate
  参考文献：
  名称：

  Synthesis, antimicrobial, and cytotoxicity studies of novel sulfur-linked quinoline–coumarin bisheterocycles

  摘要：

  A series of sulfur attached quinolines and quinoline-coumarin bisheterocycles have been synthesized by the Friedlander reaction of methyl 2-[(2,4-diaryl-3-quinolyl)sulfanyl]acetate and subsequent reaction with salicylaldehyde. These compounds were screened for their in vitro antimicrobial activity against Gram-positive, Gram-negative bacteria, and fungal pathogen. Among the 19 compounds screened, preliminary results indicated that many of the compounds demonstrated moderate to good antimicrobial activities. The cytotoxic effects against mouse fibroblasts (NIH 3T3) in vitro were evaluated for the most active compound, which displayed no toxic effects.

  DOI：

  10.1007/s00044-013-0761-7