2-(4-Methoxyphenyl)-3,6-dimethyl-2,3-dihydrochromen-4-one | 1403356-73-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(4-Methoxyphenyl)-3,6-dimethyl-2,3-dihydrochromen-4-one
• CAS: 1403356-73-9
• 化学式: C₁₈H₁₈O₃
• 分子量: 282.339
• InChiKey: RFSSRRSBNGDHPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-Methoxyphenyl)-3,6-dimethyl-2,3-dihydrochromen-4-one 在 硫酸 、 碘 、 二甲基亚砜 作用下， 反应 0.5h， 以89%的产率得到
  参考文献：
  名称：

  Efficient Synthesis of 3-Methyl-Flavanones and Evaluation of Their Anti-Bacterial Activity

  摘要：

  AbstractA series of 2‐phenyl‐2,3‐dihydrochromon‐4‐one derivatives (flavanone derivatives) were synthesized by silica gel assisted isomerization of several α‐methyl‐2′‐hydroxy chalcones in 74%–88% yield. These flavanones were further oxidized to 3‐methyl flavones by using iodine in dimethyl sulphoxide at 60°C in presence of acid. The newly synthesized derivatives were evaluated for in vitro study against Staphylococcus aureus, Micrococcus luteus and Staphylococcus epidermis.

  DOI：

  10.1002/cjoc.201200254
• 作为产物：
  描述：

  在 adsorbed H₂SO₄ on silica gel 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以86%的产率得到2-(4-Methoxyphenyl)-3,6-dimethyl-2,3-dihydrochromen-4-one
  参考文献：
  名称：

  Efficient Synthesis of 3-Methyl-Flavanones and Evaluation of Their Anti-Bacterial Activity

  摘要：

  AbstractA series of 2‐phenyl‐2,3‐dihydrochromon‐4‐one derivatives (flavanone derivatives) were synthesized by silica gel assisted isomerization of several α‐methyl‐2′‐hydroxy chalcones in 74%–88% yield. These flavanones were further oxidized to 3‐methyl flavones by using iodine in dimethyl sulphoxide at 60°C in presence of acid. The newly synthesized derivatives were evaluated for in vitro study against Staphylococcus aureus, Micrococcus luteus and Staphylococcus epidermis.

  DOI：

  10.1002/cjoc.201200254