N'-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methylamino]ethanimidamide | 1102184-20-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: N'-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methylamino]ethanimidamide
• CAS: 1102184-20-2
• 化学式: C₁₆H₂₅N₃O₂
• 分子量: 291.393
• InChiKey: XJNBREKNKTZQQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  79.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass
  申请人：Terkeltaub Robert

  公开号：US20070021496A1

  公开（公告）日：2007-01-25

  The present invention relates to improved diagnostic methods for early detection of a risk for developing an arthritic disorder in humans, and screening assays for therapeutic agents useful in the treatment of arthritic disorders, by comparing the levels of one or more indicators of altered mitochondrial function. Indicators of altered mitochondrial function include enzymes such as mitochondrial enzymes and ATP biosynthesis factors. Other indicators of altered mitochondrial function include mitochondrial mass, mitochondrial number and mitochondrial DNA content, cellular responses to elevated intracellular calcium and to apoptogens, and free radical production. Methods of treating, and of stratifying, human patients as such methods relate to disclosed indicators of altered mitchondrial function are also provided.

  本发明涉及改进的诊断方法，用于早期检测人类发展关节炎性疾病风险，并通过比较改变的线粒体功能指标的水平，筛选用于治疗关节炎性疾病的治疗剂的检测方法。改变的线粒体功能指标包括线粒体酶和ATP合成因子等酶。其他改变的线粒体功能指标包括线粒体质量、线粒体数量、线粒体DNA含量、细胞对细胞内钙离子和凋亡原的反应，以及自由基产生。还提供了与披露的改变的线粒体功能指标相关的治疗和分层人类患者的方法。