| 801291-51-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• CAS: 801291-51-0
• 化学式: C₅₇H₉₀N₆O₁₉SSi
• 分子量: 1223.52
• InChiKey: NJKXTTGPVNHMHY-QTCPNFOOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.32
• 重原子数：
  84.0
• 可旋转键数：
  36.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  309.14
• 氢给体数：
  5.0
• 氢受体数：
  21.0

反应信息

• 作为反应物：
  描述：

  N,N,N,N-四异丙基二氨基磷酸甲酯 、 在 四氮唑 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以52%的产率得到
  参考文献：
  名称：

  Reversible 5′-end biotinylation and affinity purification of synthetic RNA

  摘要：

  A reversible biotinylation phosphoramidite was synthesized and incorporated onto the 5'-end of an oligoribonucleotide on a solid phase synthesizer. After cleavage and deprotection, the crude synthetic oligomer mixture was incubated with NeutrAvidin(R) coated microspheres, and the failure sequences removed by washing with a buffer followed by treating the microspheres with tetrabutylammonium fluoride to give a high quality unmodified full-length oligoribonucleotide. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.09.019
• 作为产物：
  描述：

  二异丙基二氯硅烷 在 咪唑 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成
  参考文献：
  名称：

  Reversible 5′-end biotinylation and affinity purification of synthetic RNA

  摘要：

  A reversible biotinylation phosphoramidite was synthesized and incorporated onto the 5'-end of an oligoribonucleotide on a solid phase synthesizer. After cleavage and deprotection, the crude synthetic oligomer mixture was incubated with NeutrAvidin(R) coated microspheres, and the failure sequences removed by washing with a buffer followed by treating the microspheres with tetrabutylammonium fluoride to give a high quality unmodified full-length oligoribonucleotide. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.09.019