4-(2-乙氧基-苯基)-哌啶 | 100617-80-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 4-(2-乙氧基-苯基)-哌啶
• 英文名称: 4-(2-Aethoxy-phenyl)-piperidin
• 英文别名: 4-<2-Ethoxy-phenyl>-piperidin；4-(2-ethoxy-phenyl)-piperidine；4-(2-Ethoxyphenyl)piperidine
• CAS: 100617-80-9
• 化学式: C₁₃H₁₉NO
• mdl: MFCD05189934
• 分子量: 205.3
• InChiKey: AKFKGPKEVRALPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-[(4-fluorophenyl)sulfonyl]tetrahydro-N-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-pyran-4-carboxamide 、 4-(2-乙氧基-苯基)-哌啶 在 caesium carbonate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 生成
  参考文献：
  名称：

  Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective α-sulfone hydroxamates

  摘要：

  A series of phenyl piperidine alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing of MMP-1 and MMP-14 (MT1-MMP) and exhibit oral bioavailability in rats. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.130

文献信息

• [EN] HYDROXAMATE SULFONAMIDES AS CD23 SHEDDING INHIBITORS<br/>[FR] HYDROXAMATE SULFONAMIDES UTILISES EN TANT QU'INHIBITEURS DE L'ELIMINATION DE CD23
  申请人：CELLTECH R&D LTD

  公开号：WO2004113298A1

  公开（公告）日：2004-12-29

  A class of piperidine and related heterocyclic derivatives, C-substituted by a substituted aryl or heteroaryl moiety, and N-substituted by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

  一类哌啶和相关杂环衍生物，C位被取代的芳基或杂芳基基团取代，N位被乙磺酰基团取代，该基团在2位上被羟肟酸基团以及一系列替代取代基取代，作为CD23脱落的强效抑制剂，在治疗和/或预防过敏、炎症和肿瘤疾病方面是有用的。
• Hydroxamate sulfonamides as cd23 shedding inhibitors
  申请人：Owen Alan David

  公开号：US20060276507A1

  公开（公告）日：2006-12-07

  A class of piperidine and related heterocyclic derivatives, C-substituted by a substituted aryl or heteroaryl moiety, and N-substituted by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

  一类由吡啶和相关杂环衍生物组成，C位被取代芳基或杂芳基基团取代，N位被乙基磺酰基取代，该基团在2位被羟肟酸基团和一系列替代基团取代，是CD23剪切的有效抑制剂，可用于治疗和/或预防过敏性、炎症性和肿瘤性疾病。
• HYDROXAMATE SULFONAMIDES AS CD23 SHEDDING INHIBITORS
  申请人：Celltech R & D Limited

  公开号：EP1648868A1

  公开（公告）日：2006-04-26
• US3935227A
  申请人：——

  公开号：US3935227A

  公开（公告）日：1976-01-27
• US4007191A
  申请人：——

  公开号：US4007191A

  公开（公告）日：1977-02-08