4-(2-吗啉乙氧基)萘-1-胺双盐酸盐 | 285984-50-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 4-(2-吗啉乙氧基)萘-1-胺双盐酸盐
• 中文别名: 4-(2-吗啉乙氧基)萘-1-胺二盐酸盐
• 英文名称: 4-(2-Morpholinoethoxy)naphthalen-1-amine dihydrochloride
• 英文别名: 4-(2-morpholin-4-ylethoxy)naphthalen-1-amine;dihydrochloride
• CAS: 285984-50-1
• 化学式: C16H22Cl2N2O2
• 分子量: 345.3
• InChiKey: DBCLRCAPGPIFHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.98
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  47.7
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

文献信息

• [EN] SILICON COMPOUNDS AND THEIR USE<br/>[FR] COMPOSES DE SILICIUM ET UTILISATIONS DE CEUX-CI
  申请人：AMEDIS PHARM LTD

  公开号：WO2005044825A1

  公开（公告）日：2005-05-19

  A compound of formula (1) wherein R1, R2 and R3 are the same or different and are each alkyl, -alkyl-aryl or -alkyl-cycloalkyl; or R1-Si-R 2 taken together form heterocycloalkyl; R4 is aryl or heteroaryl, either of which is optionally substituted with -Y-R5; R5 is alkyl, cycloalkyl, heterocycloalkyl or heteroaryl; W is arylene, optionally substituted with one or more substituents selected from halogen, hydroxy, alkyl, -alkyl-aryl, -alkyl-cycloalkyl, aryl, heteroaryl, -alkylheteroaryl, -alkyl­heterocycloalkyl, -alkoxy-heterocycloalkyl, alkoxy, aryloxy, hydroxyalkyl, -NHC(O)-alkyl, -NHC(O)-aryl, -NHS(0)2-alkyl, -NH,9(0)2-aryl, cyano and -Si(R1)(R2)(R3); X is oxygen or sulphur; Y is a bond, -NH-, -0-, -S-, -Si(R6)(R7 )-, alkylene, -0-alkyl-, -S-alkyl-, -NH alkyl-, -Si(R6)(R7 )-alkyl-, heterocycloalkylene or -heterocycloalkyl-alkyl-; and R6 and R7 are the same or different and are each alkyl, -alkyl-aryl or -alkyl­ cycloalkyl; or R6-Si-R7 taken together form heterocycloalkyl; or a pharmaceutically acceptable salt thereof or a prodrug form that is oxidisable or hydrolysable to form a compound as defined above.

  式（1）的化合物，其中R1、R2和R3相同或不同，分别为烷基、-烷基-芳基或-烷基-环烷基；或R1-Si-R2一起形成杂环烷基；R4为芳基或杂芳基，任一者可选择性地用-Y-R5取代；R5为烷基、环烷基、杂环烷基或杂芳基；W为芳亚烷，可选择性地用卤素、羟基、烷基、-烷基-芳基、-烷基-环烷基、芳基、杂芳基、-烷基杂芳基、-烷基杂环烷基、-烷氧基-杂环烷基、烷氧基、芳氧基、羟基烷基、-NHC(O)-烷基、-NHC(O)-芳基、-NHS(0)2-烷基、-NH,9(0)2-芳基、氰基和-Si(R1)(R2)(R3)中选择的一个或多个取代基取代；X为氧或硫；Y为键、-NH-、-O-、-S-、-Si(R6)(R7)-、亚烷基、-O-烷基、-S-烷基、-NH烷基、-Si(R6)(R7)-烷基、杂环烷基或-杂环烷基-烷基；R6和R7相同或不同，分别为烷基、-烷基-芳基或-烷基环烷基；或R6-Si-R7一起形成杂环烷基；或其药学上可接受的盐或可被氧化或水解形成上述定义的化合物的前药形式。
• Preparation of 4-amino-1-naphthol ethers
  申请人：——

  公开号：US20030083525A1

  公开（公告）日：2003-05-01

  The present invention describes a process for preparing 4-amino-1-naphthol ethers which is characterized in that naphthol ethers are first prepared from 1-naphthols, the former are then converted to the corresponding 4-acetamino-1-naphthol ethers and then the acyl group is cleaved off, and further describes 4-acetamino-1-naphthol ethers obtained thereby.

  本发明描述了一种制备4-氨基-1-萘醚的过程，其特征在于首先从1-萘酚制备萘醚，然后将前者转化为相应的4-乙酰氨基-1-萘醚，然后裂解酰基，并进一步描述了由此获得的4-乙酰氨基-1-萘醚。
• [EN] SILYLATED HETEROCYCLYLUREA DERIVATIVES AS CYTOKINE-INHIBITORS<br/>[FR] DERIVES D'HETEROCYCLYLUREE SILYLES INHIBITEURS DES CYTOKINES
  申请人：AMEDIS PHARM LTD

  公开号：WO2004113352A1

  公开（公告）日：2004-12-29

  A compound of formula (I) Wherein R1, R2 and R3 are the same or different and are each alkyl, -aikyl-aryl or -alkyl-cycloalkyl; or R1-Si-R2 taken together form heterocycloalkyl; R4 is aryl or heteroaryl, either of which is optionally substituted with -Y-R5; R5 is alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; W is heterocyclylene optionally substituted with alkyl, -aikyl-aryl, -alkyl­ cycloalkyl, aryl, heteroaryl, -alkyl-heteroaryl or -alkyl-heterocycloalkyl; X is oxygen or sulphur; Y is a bond, -NH-, -0-, -S-, -Si(R6)(R7)-, alkylene, alkenylene, -0-alkyl-, -S-alkyl-, -NH-alkyl- or -Si(R6)(R7)-alkyl-; R6 and R7 are the same or different and are each aikyl; with the proviso that -Si(R1)(R2)(R3) is bound to a ring carbon atom of W; or a pharmaceutically acceptable salt thereof, or a prodrug form that is oxidisable or hydrolysable to form a compound as defined above.

  化合物的化学式为(I)，其中R1、R2和R3相同或不同，均为烷基、烷基芳基或烷基环烷基；或者R1-Si-R2结合形成杂环烷基；R4为芳基或杂芳基，其中任意一个可以选配有-Y-R5；R5为烷基、环烷基、杂环烷基、芳基或杂芳基；W为杂环亚基，可以选配有烷基、烷基芳基、烷基环烷基、芳基、杂芳基、烷基杂芳基或烷基杂环烷基取代基；X为氧或硫；Y为键、-NH-、-O-、-S-、-Si(R6)(R7)-、烷基、烯基、-O-烷基、-S-烷基、-NH-烷基或-Si(R6)(R7)-烷基；R6和R7相同或不同，均为烷基；但-Si(R1)(R2)(R3)必须与W的环碳原子相结合；或其药学上可接受的盐，或者是可氧化或水解成上述定义的化合物的前药形式。
• VERFAHREN ZUR HERSTELLUNG VON 4-AMINO-1-NAPHTHOLETHERN
  申请人：Bayer Chemicals AG

  公开号：EP1425261A2

  公开（公告）日：2004-06-09
• US6964963B2
  申请人：——

  公开号：US6964963B2

  公开（公告）日：2005-11-15