ethyl 2-(2-(3-chlorophenyl)-2-oxoacetyl)benzoate | 1450759-64-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: ethyl 2-(2-(3-chlorophenyl)-2-oxoacetyl)benzoate
• 英文别名: Ethyl 2-[2-(3-chlorophenyl)-2-oxoacetyl]benzoate；ethyl 2-[2-(3-chlorophenyl)-2-oxoacetyl]benzoate
• CAS: 1450759-64-4
• 化学式: C₁₇H₁₃ClO₄
• 分子量: 316.741
• InChiKey: HMUZWPBNISERLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl 2-[(3-chlorophenyl)ethynyl]benzoate 在 三苯基膦双(三氟甲磺酰亚胺)金 、 水 、 Selectfluor 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以86%的产率得到ethyl 2-(2-(3-chlorophenyl)-2-oxoacetyl)benzoate
  参考文献：
  名称：

  Gold(I)-Catalyzed Diketonization of Alkynes and Its Application for the One-Pot Synthesis of Quinoxaline Derivatives

  摘要：

  A gold(I)-catalyzed oxidative diketonization of alkynes by water in the presence of Selectfluor has been achieved. The application of the present protocol for the one-pot synthesis of quinoxaline derivatives from alkynes and o-phenylenediamines has also been successful.

  DOI：

  10.1055/s-0033-1338804

文献信息

• Gold(I)-Catalyzed Diketonization of Alkynes and Its Application for the One-Pot Synthesis of Quinoxaline Derivatives
  作者：Yunkui Liu、Xiaoling Chen、Jian Zhang、Zhenyuan Xu

  DOI：10.1055/s-0033-1338804

  日期：——

  A gold(I)-catalyzed oxidative diketonization of alkynes by water in the presence of Selectfluor has been achieved. The application of the present protocol for the one-pot synthesis of quinoxaline derivatives from alkynes and o-phenylenediamines has also been successful.