2-[5-chloro-4-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-2-fluoro-phenoxymethyl]-1H-benzoimidazole | 1036382-27-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 2-[5-chloro-4-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-2-fluoro-phenoxymethyl]-1H-benzoimidazole
• 英文别名: 3-[[4-(1H-benzimidazol-2-ylmethoxy)-2-chloro-5-fluorophenyl]methyl]-5-chloro-1H-pyrrolo[2,3-b]pyridine
• CAS: 1036382-27-0
• 化学式: C₂₂H₁₅Cl₂FN₄O
• 分子量: 441.292
• InChiKey: MKENKSYWAFYLRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
  申请人：Ibrahim Prabha N.

  公开号：US20080221148A1

  公开（公告）日：2008-09-11

  Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

  本文描述了对蛋白激酶活性有作用的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病情的方法。
• US7872018B2
  申请人：——

  公开号：US7872018B2

  公开（公告）日：2011-01-18
• [EN] COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR LA MODULATION DES KINASES, ET INDICATIONS CORRESPONDANTES
  申请人：PLEXXIKON INC

  公开号：WO2008080015A2

  公开（公告）日：2008-07-03

  [EN] Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
  [FR] Composés agissant sur les protéines kinases, et procédés d'utilisation de ces composés pour le traitement de maladies et d'affections associées à l'activité aberrante des protéines kinases.
• [EN] COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR LA MODULATION DE KINASES ET INDICATIONS POUR CELLE-CI
  申请人：PLEXXIKON INC

  公开号：WO2008080001A2

  公开（公告）日：2008-07-03

  [EN] Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
  [FR] L'invention concerne des composés actifs sur les protéine kinases, ainsi que des procédés d'utilisation de ces composés pour traiter des pathologies et des affections associées à une activité aberrante des protéines kinases.
• [EN] METHODS OF STRATIFYING AND TREATING A SUB-POPULATION OF INFLAMMATORY BOWEL DISEASE PATIENTS<br/>[FR] PROCÉDÉS DE CLASSIFICATION ET DE TRAITEMENT D'UNE SOUS-POPULATION DE PATIENTS ATTEINTS D'UNE MALADIE INTESTINALE INFLAMMATOIRE
  申请人：CEDARS SINAI MEDICAL CENTER

  公开号：WO2020113116A1

  公开（公告）日：2020-06-04

  Described herein are methods and systems for identifying subpopulations of patients having Crohn´s disease, including populations at risk of developing structuring or other severe disease, and populations susceptible to success or failure with surgical intervention. Further provided are therapies useful for treating subpopulations of patients having Crohn´s disease.