(3S,4R)-1-benzyl-N-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-ium-2-yl)-3,4-diphenyl-3-prop-2-enylazetidin-2-imine | 1332480-53-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (3S,4R)-1-benzyl-N-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-ium-2-yl)-3,4-diphenyl-3-prop-2-enylazetidin-2-imine
• CAS: 1332480-53-1
• 化学式: C₃₀H₃₃N₂O₃P
• 分子量: 500.577
• InChiKey: CAFYJGJEHVYZFV-OFSOJUDTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5,5-dimethyl-2-oxo-N-(2-phenylethynyl)-N-prop-2-enyl-1,3,2lambda5-dioxaphosphinan-2-amine 、 N-苄烯丁胺 以 甲苯 为溶剂， 反应 1.0h， 生成 、 (3S,4R)-1-benzyl-N-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-ium-2-yl)-3,4-diphenyl-3-prop-2-enylazetidin-2-imine
  参考文献：
  名称：

  Introducing a New Class of N-Phosphoryl Ynamides via Cu(I)-Catalyzed Amidations of Alkynyl Bromides

  摘要：

  We describe here the first synthesis of N-phosphoryl ynamides featuring C- and P-chirality via copper(I)-catalyzed amidative cross-couplings between phosphoramidates and phosphordiamidates with alkynyl bromides. Also featured is a tandem aza-Claisen-hetero-[2 + 2] cycloaddition for the synthesis of N-phosphoryl azetidin-2-imines.

  DOI：

  10.1021/ol201947b

文献信息

• Introducing a New Class of <i>N-</i>Phosphoryl Ynamides via Cu(I)-Catalyzed Amidations of Alkynyl Bromides
  作者：Kyle A. DeKorver、Mary C. Walton、Troy D. North、Richard P. Hsung

  DOI：10.1021/ol201947b

  日期：2011.9.16

  We describe here the first synthesis of N-phosphoryl ynamides featuring C- and P-chirality via copper(I)-catalyzed amidative cross-couplings between phosphoramidates and phosphordiamidates with alkynyl bromides. Also featured is a tandem aza-Claisen-hetero-[2 + 2] cycloaddition for the synthesis of N-phosphoryl azetidin-2-imines.