4'-monoiodofluorescein | 70763-43-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 4'-monoiodofluorescein
• 英文别名: 3',6'-dihydroxy-4'-iodo-spiro[phthalan-1,9'-xanthen]-3-one；3',6'-Dihydroxy-4'-jod-spiro[phthalan-1,9'-xanthen]-3-on；3',6'-Dihydroxy-4'-iodospiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 70763-43-8
• 化学式: C₂₀H₁₁IO₅
• 分子量: 458.209
• InChiKey: PFOVZKYDNSIGPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氯仿 、 碘 作用下， 生成 4'-monoiodofluorescein
  参考文献：
  名称：

  Lissitzky et al., Bulletin de la Societe Chimique de France, 1959, p. 389

  摘要：

  DOI：

文献信息

• [EN] NOVEL HEAVY METAL ION-HEMATEIN-COMPLEXES USEFUL AS EX VIVO CONTRAST AGENT FOR A COMPUTED TOMOGRAPHY SCANNING OF A BIOLOGICAL SAMPLE, EX VIVO METHOD FOR INVESTIGATING A BIOLOGICAL SAMPLE, AND USE OF THE COMPLEXES<br/>[FR] NOUVEAUX COMPLEXES ION DE MÉTAL LOURD-HÉMATÉINE UTILES EN TANT QU'AGENT DE CONTRASTE EX VIVO POUR UN BALAYAGE DE TOMOGRAPHIE ASSISTÉE PAR ORDINATEUR D'UN ÉCHANTILLON BIOLOGIQUE, PROCÉDÉ EX VIVO POUR EXAMINER UN ÉCHANTILLON BIOLOGIQUE, ET UTILISATION DES COMPLEXES
  申请人：UNIV MUENCHEN TECH

  公开号：WO2019073064A1

  公开（公告）日：2019-04-18

  The present invention relates to specific complexes comprising heavy metal ions having an atomic number of 23 or higher and 83 or lower (in particular Ag1+, Ba2+,Pb2 +, Gd3+ and Bi3+) and one or more hematein ligand(s). In particular, the invention relates to the use of the complexes as ex vivo contrast agents for a computed tomography scanning of a biological sample. Moreover, the invention relates to specific ex vivo methods for investigating a biological sample by means of computed tomography scanning methods, wherein the method comprises staining the biological sample with a solution comprising one or more of the complex(es); or wherein the method comprises staining the biological sample with a staining solution comprising hematein, and separately contacting the biological sample with one or more staining solution(s) comprising one or more heavy metal ions having an atomic number of 23 or higher and 83 or lower (in particular Ag1+, Ba2+,Pb2 +, Gd3+ and Bi3+).

  本发明涉及包含具有原子序数为23或更高和83或更低的重金属离子（特别是Ag1+、Ba2+、Pb2+、Gd3+和Bi3+）和一个或多个赫马丁配体的特定络合物。具体而言，本发明涉及将这些络合物用作生物样本的体外造影剂，用于计算机断层扫描。此外，本发明涉及通过计算机断层扫描方法研究生物样本的特定体外方法，其中该方法包括用含有一个或多个该络合物的溶液对生物样本进行染色；或者该方法包括用含有赫马丁的染色溶液对生物样本进行染色，并分别将生物样本与含有原子序数为23或更高和83或更低的重金属离子（特别是Ag1+、Ba2+、Pb2+、Gd3+和Bi3+）的一个或多个染色溶液接触。
• NOVEL HEAVY METAL ION-HEMATEIN-COMPLEXES USEFUL AS EX VIVO CONTRAST AGENT FOR A COMPUTED TOMOGRAPHY SCANNING OF A BIOLOGICAL SAMPLE, EX VIVO METHOD FOR INVESTIGATING A BIOLOGICAL SAMPLE, AND USE OF THE COMPLEXES
  申请人：TECHNISCHE UNIVERSITÄT MÜNCHEN

  公开号：US20200271554A1

  公开（公告）日：2020-08-27

  The present invention relates to specific complexes comprising heavy metal ions having an atomic number of 23 or higher and 83 or lower (in particular Ag 1+ , Ba 2+ , Pb 2+ , Gd 3+ and Bi 3+ ) and one or more hematein ligand(s). In particular, the invention relates to the use of the complexes as ex vivo contrast agents for a computed tomography scanning of a biological sample. Moreover, the invention relates to specific ex vivo methods for investigating a biological sample by means of computed tomography scanning methods, wherein the method comprises staining the biological sample with a solution comprising one or more of the complex(es); or wherein the method comprises staining the biological sample with a staining solution comprising hematein, and separately contacting the biological sample with one or more staining solution(s) comprising one or more heavy metal ions having an atomic number of 23 or higher and 83 or lower (in particular Ag 1+ , Ba 2+ , Pb 2+ , Gd 3+ and Bi 3+ ).
• NOVEL HEAVY METAL ION-LIGAND-COMPLEXES USEFUL AS EX VIVO CONTRAST AGENT FOR A COMPUTED TOMOGRAPHY SCANNING OF A BIOLOGICAL SAMPLE, EX VIVO METHOD FOR INVESTIGATING A BIOLOGICAL SAMPLE, AND USE OF THE COMPLEXES
  申请人：TECHNISCHE UNIVERSITÄT MÜNCHEN

  公开号：US20210371436A1

  公开（公告）日：2021-12-02

  The present invention relates to specific complexes comprising heavy metal ions having an atomic number of 29 or higher and 83 or lower (preferably 29 or higher and 81 or lower) and one or more ligand(s) selected from the group consisting of specific xanthene derivatives, preferably eosin Y and/or erythrosin B ligand(s). In particular, the invention relates to the use of the complexes as ex vivo contrast agents for a computed tomography scanning of a biological sample. Moreover, the invention relates to specific ex vivo methods for investigating a biological sample by means of computed tomography scanning methods, wherein the method comprises staining the biological sample with a solution comprising one or more of the complex(es); or wherein the method comprises staining the biological sample with a staining solution comprising one or more specific xanthenes derivatives (e.g. eosin Y and/or erythrosin B), and separately contacting the biological sample with one or more staining solution(s) comprising one or more heavy metal ions having an atomic number of 29 or higher and 83 or lower (preferably 29 or higher and 81 or lower).