6-((2-amino-4-pyrimidinyl)oxy)-N-phenyl-1-naphthalenecarboxamide | 861875-62-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-((2-amino-4-pyrimidinyl)oxy)-N-phenyl-1-naphthalenecarboxamide
• 英文别名: 6-[(2-Amino-4-pyrimidinyl)oxy]-N-phenyl-1-naphthalenecarboxamide；6-(2-aminopyrimidin-4-yl)oxy-N-phenylnaphthalene-1-carboxamide
• CAS: 861875-62-9
• 化学式: C₂₁H₁₆N₄O₂
• 分子量: 356.384
• InChiKey: BUKVJATZZMQUMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  90.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Compounds and methods of use
  申请人：Potashman Michele

  公开号：US20090176774A1

  公开（公告）日：2009-07-09

  Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对于预防和治疗HGF介导的疾病等疾病有效。该发明涵盖了新的化合物、类似物、前药和其药学上可接受的盐、制药组合物以及预防和治疗癌症等疾病和其他疾病或情况的方法。该发明还涉及制造这些化合物的过程以及在这些过程中有用的中间体。
• COMPOUNDS AND METHODS OF USE
  申请人：AMGEN INC.

  公开号：EP1713484A2

  公开（公告）日：2006-10-25
• Bicyclic Amides as Kinase Inhibitors
  申请人：Bold Guido

  公开号：US20080287427A1

  公开（公告）日：2008-11-20

  The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising en a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.
• Combinations Comprising a Vegf Receptor Inhibitor
  申请人：Billich Andreas

  公开号：US20080306058A1

  公开（公告）日：2008-12-11

  A composition comprising a VEGF receptor inhibitor and a penetration enhancer and uses thereof.
• BICYCLIC AMIDES AS KINASE INHIBITORS
  申请人：Bold Guido

  公开号：US20110301157A1

  公开（公告）日：2011-12-08

  The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.