2-{[4-(3-{2-[2-(3,4-Dimethoxy-phenyl)-ethylcarbamoyl]-ethyl}-2,6-dioxo-piperidin-3-yl)-phenylamino]-methylene}-malonic acid diethyl ester | 175436-99-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-{[4-(3-{2-[2-(3,4-Dimethoxy-phenyl)-ethylcarbamoyl]-ethyl}-2,6-dioxo-piperidin-3-yl)-phenylamino]-methylene}-malonic acid diethyl ester
• CAS: 175436-99-4
• 化学式: C₃₂H₃₉N₃O₉
• 分子量: 609.676
• InChiKey: DPXQYCSQBOTOOM-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-{[4-(3-{2-[2-(3,4-Dimethoxy-phenyl)-ethylcarbamoyl]-ethyl}-2,6-dioxo-piperidin-3-yl)-phenylamino]-methylene}-malonic acid diethyl ester 以 二苯醚 为溶剂， 以66%的产率得到6-(3-{2-[2-(3,4-Dimethoxy-phenyl)-ethylcarbamoyl]-ethyl}-2,6-dioxo-piperidin-3-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  Syntheses and exploration of new biological activities in ethyl 6/7-substituted and 6, 7-disubstituted quinolin-4-one-3-carboxylates

  摘要：

  Syntheses of a number of ethyl 1H, 4H-quinolin-4-one-3-carboxylates carrying substituted piperidinedione ring at position 6 (25 & 31-35), tetrahydrofuranone (37) or tetraydropyridazinone ring (39) at position 7 and hydroxy and hydroxymethyl substituents at positions 6 and 7 respectively (41) of the quinolone ring, are reported here, of these compounds on the in vitro heme polymerase activity of Plasmodia and on the in vitro fungal growth are described.

  DOI：

  10.1016/0960-894x(95)00577-g
• 作为产物：
  描述：

  3-(4-nitrophenyl)-2,6-piperdidinedione-3-propionic acid 在 Ra-Ni 氢气 作用下， 以 甲醇 为溶剂， 生成 2-{[4-(3-{2-[2-(3,4-Dimethoxy-phenyl)-ethylcarbamoyl]-ethyl}-2,6-dioxo-piperidin-3-yl)-phenylamino]-methylene}-malonic acid diethyl ester
  参考文献：
  名称：

  Syntheses and exploration of new biological activities in ethyl 6/7-substituted and 6, 7-disubstituted quinolin-4-one-3-carboxylates

  摘要：

  Syntheses of a number of ethyl 1H, 4H-quinolin-4-one-3-carboxylates carrying substituted piperidinedione ring at position 6 (25 & 31-35), tetrahydrofuranone (37) or tetraydropyridazinone ring (39) at position 7 and hydroxy and hydroxymethyl substituents at positions 6 and 7 respectively (41) of the quinolone ring, are reported here, of these compounds on the in vitro heme polymerase activity of Plasmodia and on the in vitro fungal growth are described.

  DOI：

  10.1016/0960-894x(95)00577-g