tert-butyl((12Z,17Z,20Z,23Z,26Z)-dotriaconta-12,17,20,23,26-pentaen-1-yloxy)dimethylsilane | 1260225-96-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: tert-butyl((12Z,17Z,20Z,23Z,26Z)-dotriaconta-12,17,20,23,26-pentaen-1-yloxy)dimethylsilane
• 英文别名: tert-butyl-[(12Z,17Z,20Z,23Z,26Z)-dotriaconta-12,17,20,23,26-pentaenoxy]-dimethylsilane
• CAS: 1260225-96-4
• 化学式: C₃₈H₇₀OSi
• 分子量: 571.059
• InChiKey: NQNBJLQQRIFHET-JPLWDHQASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.61
• 重原子数：
  40
• 可旋转键数：
  28
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tert-butyl((12Z,17Z,20Z,23Z,26Z)-dotriaconta-12,17,20,23,26-pentaen-1-yloxy)dimethylsilane 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以88%的产率得到(12Z,17Z,20Z,23Z,26Z)-dotriaconta-12,17,20,23,26-pentaen-1-ol
  参考文献：
  名称：

  Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids

  摘要：

  First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, 34:5n5, and three other unlabeled very long chain C30-32 containing polyunsaturated fatty acids are reported. These syntheses were achieved by coupling chemically modified C22- and C20-containing polyunsaturated fatty acids with carbanions derived from arylalkyl sulfones, followed by sodium amalgam-mediated desulfonylation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.139
• 作为产物：
  描述：

  bromo(12-((tert-butyldimethylsilyl)oxy)dedecyl)triphenylphosphorane 、 (all-Z)-Eicosa-5,8,11,14-tetraenal 在 双(三甲基硅烷基)氨基钾 作用下， 以 甲苯 为溶剂， 反应 2.25h， 以0.177 g的产率得到tert-butyl((12Z,17Z,20Z,23Z,26Z)-dotriaconta-12,17,20,23,26-pentaen-1-yloxy)dimethylsilane
  参考文献：
  名称：

  Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids

  摘要：

  First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, 34:5n5, and three other unlabeled very long chain C30-32 containing polyunsaturated fatty acids are reported. These syntheses were achieved by coupling chemically modified C22- and C20-containing polyunsaturated fatty acids with carbanions derived from arylalkyl sulfones, followed by sodium amalgam-mediated desulfonylation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.139

文献信息

• Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids
  作者：Ghulam M. Maharvi、Albert O. Edwards、Abdul H. Fauq

  DOI：10.1016/j.tetlet.2010.09.139

  日期：2010.12

  First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, 34:5n5, and three other unlabeled very long chain C30-32 containing polyunsaturated fatty acids are reported. These syntheses were achieved by coupling chemically modified C22- and C20-containing polyunsaturated fatty acids with carbanions derived from arylalkyl sulfones, followed by sodium amalgam-mediated desulfonylation. (C) 2010 Elsevier Ltd. All rights reserved.