N-[(3,5-dimethyl-1H-pyrazol-4-yl)(naphthalen-1-yl)methyl]acetamide | 1104872-60-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[(3,5-dimethyl-1H-pyrazol-4-yl)(naphthalen-1-yl)methyl]acetamide
• 英文别名: N-[(3,5-dimethyl-1H-pyrazol-4-yl)-naphthalen-1-ylmethyl]acetamide
• CAS: 1104872-60-7
• 化学式: C₁₈H₁₉N₃O
• 分子量: 293.368
• InChiKey: RREDGLOAXDQWKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  57.8
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-[2-acetyl-1-(naphthalen-1-yl)-3-oxobutyl]propionamide 在 肼 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以95%的产率得到N-[(3,5-dimethyl-1H-pyrazol-4-yl)(naphthalen-1-yl)methyl]acetamide
  参考文献：
  名称：

  N-(α-Amidoalkyl)benzotriazole-mediated synthesis of β′-amido β-diketones: a general synthetic protocol for N-[β-(3,5-di and 1,3,5-trisubstituted pyrazol-4-yl)alkyl] amides

  摘要：

  Various beta '-amido-beta-diketones were first synthesized with N-(alpha-amidoalkyl)benzotriazole-mediated amidoalkylation of 1,3-diketones in moderate yields. These intermediates undergo rapid condensation with hydrazines to give the corresponding N-[beta-(3,5-di and 1,3,5-trisubstituted pyrazol-4-yl)alkyl]amides. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.10.047

文献信息

• N-(α-Amidoalkyl)benzotriazole-mediated synthesis of β′-amido β-diketones: a general synthetic protocol for N-[β-(3,5-di and 1,3,5-trisubstituted pyrazol-4-yl)alkyl] amides
  作者：İlhami Çelik、Nevin Kanışkan、Şule Kökten

  DOI：10.1016/j.tet.2008.10.047

  日期：2009.1

  Various beta '-amido-beta-diketones were first synthesized with N-(alpha-amidoalkyl)benzotriazole-mediated amidoalkylation of 1,3-diketones in moderate yields. These intermediates undergo rapid condensation with hydrazines to give the corresponding N-[beta-(3,5-di and 1,3,5-trisubstituted pyrazol-4-yl)alkyl]amides. (C) 2008 Elsevier Ltd. All rights reserved.