7-methoxy-3,4-dihydro-[2]naphthoic acid | 854817-20-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-methoxy-3,4-dihydro-[2]naphthoic acid
• 英文别名: 7-Methoxy-3,4-dihydro-[2]naphthoesaeure；7-Methoxy-3,4-dihydronaphthalene-2-carboxylic acid
• CAS: 854817-20-2
• 化学式: C₁₂H₁₂O₃
• 分子量: 204.225
• InChiKey: DBSBRJGTHOQYOH-UHFFFAOYSA-N

物化性质

• 熔点：
  149.5-150 °C
• 沸点：
  352.2±42.0 °C(Predicted)
• 密度：
  1.246±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-methoxy-3,4-dihydro-[2]naphthoic acid 在 sulfur 作用下， 生成 7-methoxy-2-naphthoic acid
  参考文献：
  名称：

  Holmes; Trevoy, Canadian Journal of Research, Section B: Chemical Sciences, 1944, vol. 22, p. 56,63

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(4-甲氧基)苯基丁酸乙酯 生成 7-methoxy-3,4-dihydro-[2]naphthoic acid
  参考文献：
  名称：

  Holmes; Trevoy, Canadian Journal of Research, Section B: Chemical Sciences, 1944, vol. 22, p. 56,63

  摘要：

  DOI：

文献信息

• 3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands
  申请人：INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

  公开号：EP1683790A1

  公开（公告）日：2006-07-26

  The invention relates to 3,4-dihydro-2-naphthamide derivatives of formula (I), pharmaceutical compositions containing them and their therapeutic applications as partial agonists or antagonists of the dopamine D3 receptor for the treatment of neuropsychological disorders.

  该发明涉及公式(I)的3,4-二氢-2-萘酰胺衍生物，包含它们的药物组合物以及它们作为多巴胺D3受体的部分激动剂或拮抗剂在治疗神经心理障碍方面的治疗应用。
• 3, 4-DIHYDRO-2-NAPHTHAMIDE DERIVATIVES AS SELECTIVE DOPAMINE D3 LIGANDS
  申请人：Sokoloff Pierre

  公开号：US20090124630A1

  公开（公告）日：2009-05-14

  The invention relates to 3,4-dihydro-2-naphthamide derivatives of formula (I), pharmaceutical compositions containing them and their therapeutic applications as partial agonists or antagonists of the dopamine D3 receptor for the treatment of neuropsychological disorders.

  本发明涉及式(I)的3,4-二氢-2-萘酰胺衍生物，含有它们的药物组合物以及它们作为多巴胺D3受体的部分激动剂或拮抗剂的治疗应用于神经心理障碍的治疗。
• Tomato infectious chlorosis virus causes leaf yellowing and reddening of tomato in Italy
  作者：A. M. Vaira、G. P. Accotto、M. Vecchiati、M. Bragaloni

  DOI：10.1007/bf03039998

  日期：2002.6

  Since autumn 2000, severe and widespread chlorosis, sometimes associated with redness, has been observed in greenhouse tomatoes in different regions of Italy. A total of 104 samples were analyzed for tomato infectious chlorosis virus (TICV), by a one-step RT-PCR procedure. In some areas of central Italy and Sardinia, the symptom was consistently correlated with the presence of TICV. The RT-PCR procedure enabled rapid and reliable detection of TICV from field samples. Sequence analysis of the amplified 501-bp fragment, part of the HSP70 coding region, revealed an identity of 99% with the TICV sequence in the GenBank database. A digoxigenin-labeled DNA probe was also produced and successfully tested in dot blot assays. This is the first report of TICV causing epidemics in Europe.
• 3,4-DIHYDRO-2-NAPHTHAMIDE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
  申请人：INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

  公开号：EP1841752B1

  公开（公告）日：2008-12-10
• US7875617B2
  申请人：——

  公开号：US7875617B2

  公开（公告）日：2011-01-25