2a.3.4.5-Tetrahydro-acenaphtho<4.5-d>-v-triazol | 95196-71-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2a.3.4.5-Tetrahydro-acenaphtho<4.5-d>-v-triazol
• 英文别名: 5,5a,6,8-tetrahydro-4H-acenaphtho[4,5-d][1,2,3]triazole；3,4,5-Triazatetracyclo[6.6.1.02,6.011,15]pentadeca-1(14),2,5,11(15),12-pentaene
• CAS: 95196-71-7
• 化学式: C₁₂H₁₁N₃
• 分子量: 197.239
• InChiKey: NPKRGPXSBKMDDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Compounds and methods
  申请人：——

  公开号：US20030220371A1

  公开（公告）日：2003-11-27

  Compounds of this invention are non-peptide, reversible inhibitors of type 2 methionine aminopeptidase, useful in treating conditions mediated by angiogenesis, such as cancer, haemangioma, proliferative retinophathy, rheumatoid arthritis, atherosclerotic neovascularization, psoriasis, ocular neovascularization and obesity.

  本发明的化合物是非肽类、可逆的第2型蛋氨酸氨肽酶抑制剂，可用于治疗由血管生成介导的疾病，如癌症、血管瘤、增殖性视网膜病变、类风湿关节炎、动脉粥样硬化性新生血管生成、银屑病、眼部新生血管生成和肥胖症。
• Triazole inhibitors of type 2 methionine aminopeptidase
  申请人：Kallander S. Lara

  公开号：US20050004116A1

  公开（公告）日：2005-01-06

  Disclosed are compounds which are non-peptide, reversible inhibitors of type 2 methionine aminopeptidase, useful in treating conditions mediated by angiogenesis, such as cancer, haemangioma, proliferative retinopathy, rheumatoid arthritis, atherosclerotic neovascularization, psoriasis, ocular neovascularization and obesity.

  本发明涉及一类非肽类、可逆抑制2型甲硫氨肽酶的化合物，用于治疗由血管生成介导的疾病，例如癌症、血管瘤、增生性视网膜病变、类风湿性关节炎、动脉粥样硬化性新生血管形成、牛皮癣、眼部新生血管形成和肥胖症。
• Methionine aminopeptidase and methods of use
  申请人：Palmer Leslie

  公开号：US20070077641A1

  公开（公告）日：2007-04-05

  Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

  发明了非肽类TPO模拟剂。同时发明了一种治疗血小板减少症的方法，包括在需要的哺乳动物中，如人类，向这样的哺乳动物施用所选的羟基-1-偶氮苯衍生物的有效量。