N-(4-Bromobenzyl)-N'-naphthalen-2-ylmethyl-5-trifluoromethylbenzene-1,3-diamine | 601492-15-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(4-Bromobenzyl)-N'-naphthalen-2-ylmethyl-5-trifluoromethylbenzene-1,3-diamine
• 英文别名: 1-N-[(4-bromophenyl)methyl]-3-N-(naphthalen-2-ylmethyl)-5-(trifluoromethyl)benzene-1,3-diamine
• CAS: 601492-15-3
• 化学式: C₂₅H₂₀BrF₃N₂
• 分子量: 485.346
• InChiKey: CQWDECPPLQBHAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Novel potassium channels modulators
  申请人：4SC AG

  公开号：US20040009973A1

  公开（公告）日：2004-01-15

  The invention relates to compounds having the Formula (I) 1 or a salt, or a physiologically functional derivative, or a prodrug thereof, wherein the amine substituent is in the meta or para-position to the amine moiety of the compound of Formula (I); (A) and (B) each independently represent an aromatic hydrocarbon group which optionally contains one or more heteroatoms selected from the group consisting of S, O and N, wherein the heteroatom N is optionally substituted with R 5 , and/or the heteroatom S is optionally bonded to ═O or (═O) 2 ;

  本发明涉及具有以下式（I）的化合物1或其盐、生理功能衍生物或前药，其中氨基取代基位于式（I）化合物的氨基部分的间位或对位；（A）和（B）各自独立地表示芳香烃基，其可以包含选自S、O和N的一个或多个杂原子，其中杂原子N可以选配R5，和/或杂原子S可以与═O或(═O)2键合。
• [EN] NOVEL POTASSIUM CHANNELS MODULATORS<br/>[FR] NOUVEAUX MODULATEURS DES CANAUX POTASSIQUES
  申请人：4SC AG

  公开号：WO2003076388A2

  公开（公告）日：2003-09-18

  The invention relates to compounds having the Formula (I) or a salt, or a physiologically functional derivative, or a prodrug thereof, wherein the amine substituent is in the meta or para-position to the amine moiety of the compound of Formula (I); (A) and (B) each independently represent an aromatic hydrocarbon group which optionally contains one or more heteroatoms selected from the group consisting of S, O and N, wherein the heteroatom N is optionally substituted with R5 , and/or the heteroatom S is optionally bonded to =O or (=O)2.