5-Naphthalen-2-yl-2,4-dihydro-pyrazol-3-one | 78120-49-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-Naphthalen-2-yl-2,4-dihydro-pyrazol-3-one
• 英文别名: 5-(naphthalen-2-yl)-2,4-dihydro-3H-pyrazol-3-one；3-naphthalen-2-yl-1,4-dihydropyrazol-5-one
• CAS: 78120-49-7
• 化学式: C₁₃H₁₀N₂O
• 分子量: 210.235
• InChiKey: AYGSETQECLMTDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.06
• 重原子数：
  16.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  41.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

文献信息

• Pyrazole derivatives, compositions containing such compounds and methods of use
  申请人：Parmee R. Emma

  公开号：US20050272794A1

  公开（公告）日：2005-12-08

  Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

  揭示了附有萘基团的吡唑类化合物。这些化合物可用于治疗2型糖尿病及相关疾病。还包括药物组合物和治疗方法。
• PYRAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE
  申请人：Parmee Emma R.

  公开号：US20090176854A1

  公开（公告）日：2009-07-09

  Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

  本发明揭示了连接有萘基团的吡唑类化合物。这些化合物可用于治疗2型糖尿病及相关疾病。还包括制药组合物和治疗方法。
• RUBBER COMPOSITION, RUBBER MATERIAL, USE OF SAME AND ADDITIVE
  申请人：Otsuka Chemical Co., Ltd.

  公开号：EP3845591A1

  公开（公告）日：2021-07-07

  The present invention provides a rubber composition that can exhibit excellent low heat build-up, tear strength, and durability; and a rubber composition having excellent low heat build-up, tear strength, and durability, by incorporating a compound represented by the following formula (1) or (2), or a salt of the compound. In the formula (1), R1, R2, R3, and R4 are the same or different, and each represents a hydrogen atom, an alkyl group, or the like; R3 and R4 may be taken together to form an alkylidene group, and any two of R2, R3, and R4 may be taken together to form an alkylene group; and each of these groups may have one or more substituents. In the formula (2), R5, R7, and R8 are the same or different, and each represents a hydrogen atom or an amino group; and R6 represents an alkyl group or an aralkyl group; and each of these groups may have one or more substituents.

  本发明通过加入下式（1）或（2）所代表的化合物或该化合物的盐，提供了一种可表现出优异的低热积聚性、撕裂强度和耐久性的橡胶组合物；以及一种具有优异的低热积聚性、撕裂强度和耐久性的橡胶组合物。 在式 (1) 中，R1、R2、R3 和 R4 相同或不同，且各自代表氢原子、烷基或类似物；R3 和 R4 可结合在一起形成亚烷基，R2、R3 和 R4 中的任意两个可结合在一起形成亚烷基；这些基团中的每个基团可具有一个或多个取代基。 在式 (2) 中，R5、R7 和 R8 相同或不同，且各自代表氢原子或氨基；R6 代表烷基或芳烷基；这些基团中的每一个都可以有一个或多个取代基。
• US7598285B2
  申请人：——

  公开号：US7598285B2

  公开（公告）日：2009-10-06
• US7799818B2
  申请人：——

  公开号：US7799818B2

  公开（公告）日：2010-09-21