(4bR,6R,7R,8aR)-4b-benzyl-N-(6-bromo-2-methylpyridin-3-yl)-6,7-dihydroxy-6-methyl-7-phenyl-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-2-carboxamide | 1206876-96-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (4bR,6R,7R,8aR)-4b-benzyl-N-(6-bromo-2-methylpyridin-3-yl)-6,7-dihydroxy-6-methyl-7-phenyl-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-2-carboxamide
• 英文别名: (4bR,6R,7R,8aR)-4b-benzyl-N-(6-bromo-2-methylpyridin-3-yl)-6,7-dihydroxy-6-methyl-7-phenyl-8,8a,9,10-tetrahydro-5H-phenanthrene-2-carboxamide
• CAS: 1206876-96-1
• 化学式: C₃₅H₃₅BrN₂O₃
• 分子量: 611.579
• InChiKey: WUZMORZDWRQWAM-NQGIHCFJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  41
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  82.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] PHENANTHRENONE COMPOUNDS, COMPOSITIONS AND METHODS<br/>[FR] COMPOSÉS DE PHÉNANTHRÉNONE, COMPOSITIONS ET PROCÉDÉS
  申请人：PFIZER

  公开号：WO2010013158A1

  公开（公告）日：2010-02-04

  The present invention is directed to compounds of Formula (I) or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.

  本发明涉及化合物的公式（I）或其盐，这些化合物是糖皮质激素受体的调节剂。本发明的化合物和盐在治疗由糖皮质激素受体活性介导的疾病方面具有用途。
• PHENATHRENONE COMPOUNDS, COMPOSITONS AND METHODS
  申请人：Rucker Paul V.

  公开号：US20100069444A1

  公开（公告）日：2010-03-18

  The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.

  本发明涉及式I的化合物：或其盐，它们是糖皮质激素受体的调节剂。本发明的化合物和盐在治疗由糖皮质激素受体活性介导的疾病方面是有用的。
• PHENANTHRENONE COMPOUNDS, COMPOSITIONS AND METHODS
  申请人：RUCKER Paul V.

  公开号：US20120157502A1

  公开（公告）日：2012-06-21

  The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.

  本发明涉及公式I的化合物：或其盐，它们是糖皮质激素受体的调节剂。本发明的化合物和盐在治疗由糖皮质激素受体活性介导的疾病方面是有用的。
• US8148409B2
  申请人：——

  公开号：US8148409B2

  公开（公告）日：2012-04-03
• US8552035B2
  申请人：——

  公开号：US8552035B2

  公开（公告）日：2013-10-08