2-Piperidino-1,4-dioxan | 38817-73-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 2-Piperidino-1,4-dioxan
• 英文别名: N-(Dioxanyl)-piperidin；1-[1,4]dioxanyl-piperidine；Piperidinodioxane；1-(1,4-dioxan-2-yl)piperidine
• CAS: 38817-73-1
• 化学式: C₉H₁₇NO₂
• 分子量: 171.239
• InChiKey: SUPNGXZXBSSNNZ-UHFFFAOYSA-N

物化性质

• 沸点：
  246.6±30.0 °C(Predicted)
• 密度：
  1.072±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME
  申请人：The Board of Trustees of the University of Illinois

  公开号：EP2456757A2

  公开（公告）日：2012-05-30
• ORGANOMAGNESIUM SYNTHESIS AGENT
  申请人：Haber Steffen

  公开号：US20090173914A1

  公开（公告）日：2009-07-09

  An organomagnesium synthesis agent, a process for preparing this synthesis agent, and its use.
• HIV INHIBITING 5-HETEROCYCLYL PYRIMIDINES
  申请人：Guillemont Jerôme Emile Georges

  公开号：US20090181993A1

  公开（公告）日：2009-07-16

  HIV replication inhibitors of formula (I), N-oxides, pharmaceutically acceptable addition salts, quaternary amines or stereoisomeric forms thereof, wherein -a 1 =a 2 -a 3 =a 4 - is —CH═CH—CH═CH—, —N═CH—CH═CH—, —N═CH—N═CH—, —N═CH—CH═N—, —N═N—CH═CH—; -b 1 =b 2 -b 3 =b 4 - is —CH═CH—CH═CH—, —N═CH—CH═CH—, —N═CH—N═CH—, —N═CH—CH═N—, —N═N—CH═CH—; R 1 is hydrogen; aryl; formyl; C 1-6 alkylcarbonyl; optionally substituted C 1-6 alkyl; C 1-6 alkyloxycarbonyl; R 2 is OH; halo; optionally substituted C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl; substituted carbonyl; carboxyl; CN; nitro; amino; substituted amino; polyhalomethyl; polyhalomethylthio; S(═O) p R 6 ; C(═NH)R 6 ; R 2a is CN; amino; substituted amino; optionally substituted C1-6alkyl; halo; optionally substituted C 1-6 alkyloxy; substituted carbonyl; —CH═N—NH—C(O)—R 10 ; optionally substituted C 1-6 alkyloxyC 1-6 alkyl; substituted C 1-6 alkenyl or C 2-6 alkynyl; —C(═N—O—R 8 )—C 1-4 alkyl; R 7 or —X 3 —R 3 ; X 1 is —NR 1 —, —O—, —C(═O)—, —CH 2 —, —CHOH—, —S—, —S(═O) p —R 3 is CN; amino; C 1-6 alkyl; halo; optionally substituted C 1-6 alkyloxy; substituted carbonyl; —CH═N—NH—C(O)—R 16 ; substituted C 1-6 alkyl; optionally substituted C 1-6 alkyloxyC 1-6 alkyl; substituted C 2-6 alkenyl or C 2-6 alkynyl; —C(═N—O—R 8 )—C 1-4 alkyl; R 7 ; —X 3 —R 7 ; R 4 is halo; OH; optionally substituted C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl; C 3-7 cycloalkyl; C 1-6 alkyloxy; CN; nitro; polyhaloC 1-6 alkyl; polyhaloC 1-6 alkyloxy; substituted carbonyl; formyl; amino; mono- or di(C 1-4 alkyl)amino or R 7 ; R 5 is a 5- or 6-membered completely unsaturated ring system wherein 1-4 ring members are nitrogen, oxygen or sulfur; which ring may optionally be substituted and may optionally be annelated with a benzene ring; methods for their preparation and pharmaceutical compositions comprising them. The invention also relates to the use of these compounds for the prevention or the treatment of HIV infection.
• US8575342B2
  申请人：——

  公开号：US8575342B2

  公开（公告）日：2013-11-05
• US9534001B2
  申请人：——

  公开号：US9534001B2

  公开（公告）日：2017-01-03