4-fluoro-8-(4-fluorophenyl)-9-{6-[(3-hydroxypropyl){3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propyl}amino]hexyl}-6,7-dihydro-5H-benzo[7]annulen-3-ol | 1353007-12-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-fluoro-8-(4-fluorophenyl)-9-{6-[(3-hydroxypropyl){3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propyl}amino]hexyl}-6,7-dihydro-5H-benzo[7]annulen-3-ol
• 英文别名: 1-fluoro-6-(4-fluorophenyl)-5-[6-[3-hydroxypropyl-[3-(4,4,5,5,5-pentafluoropentylsulfonyl)propyl]amino]hexyl]-8,9-dihydro-7H-benzo[7]annulen-2-ol
• CAS: 1353007-12-1
• 化学式: C₃₄H₄₄F₇NO₄S
• 分子量: 695.782
• InChiKey: VQXQSNLNYFOGQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  47
• 可旋转键数：
  19
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• 6,7-DIHYDRO-5H-BENZO[7]ANNULENE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, PHARMACEUTICAL PREPARATIONS COMPRISING THEM, AND THE USE THEREOF FOR PRODUCTION OF MEDICAMENTS
  申请人：Wintermantel Tim

  公开号：US20130252890A1

  公开（公告）日：2013-09-26

  The invention relates to selective oestrogen receptor modulators (SERM) and methods of production thereof, use thereof for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular of bleeding disorders, osteoporosis, endometriosis, myomata, hormone-dependent tumours, for hormone replacement therapy and for contraception.

  该发明涉及选择性雌激素受体调节剂（SERM）及其生产方法，以及将其用于治疗和/或预防疾病以及将其用于生产用于治疗和/或预防疾病的药物产品，特别是用于出血性疾病、骨质疏松症、子宫内膜异位症、子宫肌瘤、激素依赖性肿瘤、激素替代疗法和避孕。
• 6,7-DIHYDRO-5H-BENZO[7]ANNULEN-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG, PHARMAZEUTISCHE PRÄPARATE DIE DIESE ENTHALTEN, SOWIE DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN
  申请人：Bayer Intellectual Property GmbH

  公开号：EP2585435A1

  公开（公告）日：2013-05-01
• POLYMERIC BLENDS AND RELATED OPTOELECTRONIC DEVICES
  申请人：Raynergy Tek Inc.

  公开号：EP2828903A1

  公开（公告）日：2015-01-28
• [DE] 6,7-DIHYDRO-5H-BENZO[7]ANNULEN-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG, PHARMAZEUTISCHE PRÄPARATE DIE DIESE ENTHALTEN, SOWIE DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN<br/>[EN] 6,7-DIHYDRO-5H-BENZO[7]ANNULENE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, PHARMACEUTICAL PREPARATIONS COMPRISING THEM, AND THE USE THEREOF FOR PRODUCTION OF MEDICAMENTS<br/>[FR] DÉRIVÉS DE 6,7-DIHYDRO-5H-BENZO[7]ANNULÈNE, LEUR PROCÉDÉ DE PRÉPARATION, PRÉPARATIONS PHARMACEUTIQUES LES CONTENANT ET LEUR UTILISATION POUR LA FABRICATION DE PRODUITS PHARMACEUTIQUES
  申请人：BAYER PHARMA AG

  公开号：WO2011161101A1

  公开（公告）日：2011-12-29

  Die Erfindung betrifft selektive Estrogen Receptor Modulatoren (SERM) und Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere von Blutungsbeschwerden, Osteoporose, Endometriose, Myomen, hormonabhängigen Tumoren, zur Hormonersatztherapie und zur Kontrazeption.
• [EN] CONJUGATED POLYMERS COMPRISING A BITHIOPHENE - IMIDE - BASED UNIT AND THEIR USE IN OPTOELECTRONIC DEVICES<br/>[FR] POLYMÈRES CONJUGUÉS COMPRENANT UNE UNITÉ À BASE BITHIOPHÈNE-IMIDE ET LEUR UTILISATION DANS DES DISPOSITIFS OPTOÉLECTRONIQUES
  申请人：POLYERA CORP

  公开号：WO2013142845A1

  公开（公告）日：2013-09-26

  Disclosed are certain polymeric compounds and their use as organic semiconductors in organic and hybrid optical, optoelectronic, and/or electronic devices such as photovoltaic cells, light emitting diodes, light emitting transistors, and field effect transistors. The disclosed compounds can provide improved device performance, for example, as measured by power conversion efficiency, fill factor, open circuit voltage, field-effect mobility, on/off current ratios, and/or air stability when used in photovoltaic cells or transistors. The disclosed compounds can have good solubility in common solvents enabling device fabrication via solution processes.