6-acetamido-3,4-dihydro-2,2,7,8-tetramethyl-2H-benzopyran | 153782-52-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6-acetamido-3,4-dihydro-2,2,7,8-tetramethyl-2H-benzopyran
• CAS: 153782-52-6
• 化学式: C₁₅H₂₁NO₂
• 分子量: 247.337
• InChiKey: NAMHFZSZBZIZRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.37
• 重原子数：
  18.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  38.33
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  6-acetamido-3,4-dihydro-2,2,7,8-tetramethyl-2H-benzopyran 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以96%的产率得到6-amino-3,4-dihydro-2,2,7,8-tetramethyl-2H-benzopyran hydrochloride
  参考文献：
  名称：

  The fischer indolisation reaction and the synthesis of dihydroindenoindoles

  摘要：

  The Fischer reaction between indanones and certain alkoxyarylhydrazines fails; the indanones are returned unreacted and the arylhydrazines are converted into the corresponding alkoxy-2-chloroarylamines and other products. A new N-amination route to arylhydrazines from the arylamines has been developed and it has been demonstrated that problems with the indolisation of alkoxyarylhydrazones can be circumvented by ring closures of their O-tosylated analogues. Some results using the Lepke synthesis of indoles are recorded.

  DOI：

  10.1016/s0040-4020(01)81911-6
• 作为产物：
  描述：

  4-(t-butyldimethylsilyloxy)-2,3-dimethylaniline 在 盐酸 、 sodium 作用下， 以 甲醇 、 乙醇 、 苯 为溶剂， 反应 23.0h， 生成 6-acetamido-3,4-dihydro-2,2,7,8-tetramethyl-2H-benzopyran
  参考文献：
  名称：

  The fischer indolisation reaction and the synthesis of dihydroindenoindoles

  摘要：

  The Fischer reaction between indanones and certain alkoxyarylhydrazines fails; the indanones are returned unreacted and the arylhydrazines are converted into the corresponding alkoxy-2-chloroarylamines and other products. A new N-amination route to arylhydrazines from the arylamines has been developed and it has been demonstrated that problems with the indolisation of alkoxyarylhydrazones can be circumvented by ring closures of their O-tosylated analogues. Some results using the Lepke synthesis of indoles are recorded.

  DOI：

  10.1016/s0040-4020(01)81911-6